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【结 构 式】 
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【药物名称】 【化学名称】3-[4-(5-Methyl-4-phenylpyrazol-1-yl)piperidin-1-ylmethyl]benzonitrile 【CA登记号】 【 分 子 式 】C23H24N4 【 分 子 量 】356.47453 |
【开发单位】Merck Sharp & Dohme (Originator) 【药理作用】Antidepressants, Antipsychotic Drugs, Mood Disorders, Treatment of, PSYCHOPHARMACOLOGIC DRUGS, Dopamine D4 Antagonists |
合成路线1
N-Boc-4-Hydroxypiperidine (I) was converted to the mesylate (II) with methanesulfonyl chloride and pyridine. Then, alkylation of 3-methyl-4-phenylpyrazole (III) with (II) in the presence of NaH yielded a mixture of regioisomeric pyrazoles (IV) and (V), which were separated using flash chromatography. The required isomer (IV) was subsequently treated with HCl in Et2O to remove the Boc protecting group. The resulting piperidine (VI) was finally alkylated with 3-(bromomethyl)benzonitrile (VII) to afford the title compound.
| 【1】 Bonner, K.; Jones, E.A.; Moore, K.W.; et al.; 4-N-Linked-heterocyclic piperidine derivatives with high affinity and selectivity for human dopamine D4 receptors. Bioorg Med Chem Lett 1999, 9, 9, 1285. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 18625 | tert-butyl 4-hydroxy-1-piperidinecarboxylate | C10H19NO3 | 详情 | 详情 | |
| (II) | 25308 | tert-butyl 4-[(methylsulfonyl)oxy]-1-piperidinecarboxylate | C11H21NO5S | 详情 | 详情 | |
| (III) | 25309 | 3-methyl-4-phenyl-1H-pyrazole | 3566-44-7 | C10H10N2 | 详情 | 详情 |
| (IV) | 25310 | tert-butyl 4-(5-methyl-4-phenyl-1H-pyrazol-1-yl)-1-piperidinecarboxylate | C20H27N3O2 | 详情 | 详情 | |
| (V) | 25311 | tert-butyl 4-(3-methyl-4-phenyl-1H-pyrazol-1-yl)-1-piperidinecarboxylate | C20H27N3O2 | 详情 | 详情 | |
| (VI) | 25312 | 4-(5-methyl-4-phenyl-1H-pyrazol-1-yl)piperidine | C15H19N3 | 详情 | 详情 | |
| (VII) | 13244 | alpha-Bromo-m-tolunitrile; 3-(Bromomethyl)benzonitrile | 28188-41-2 | C8H6BrN | 详情 | 详情 |