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【结 构 式】 
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【分子编号】16623 【品名】methyl 2,4-dihydroxybenzoate 【CA登记号】2150-47-2 |
【 分 子 式 】C8H8O4 【 分 子 量 】168.14912 【元素组成】C 57.14% H 4.8% O 38.06% |
合成路线1
该中间体在本合成路线中的序号：(I)The Western fragment (VI) of SC-53228 was derived from methyl 2,4-dihydroxybenzoate (I). Allylation of this material under standard conditions (allyl bromide, potassium carbonate, DMF) afforded the 4-allyl ether as the predominant product along with a smaller quantity (approx. 5%) of the 2-allyl ether. This mixture was subjected to thermally induced Claisen rearrangement (neat, 190 C) to access the requisite tetrasubstituted aromatic nucleus (II). The yield for these two steps was approx. 55%. Cyclopropanation of the allyl group was best effected by the Denmark modification of Simmons Smith reaction (Et2Zn, Cl(CH2)2Cl, ClCH2l). This process proved to be somewhat capricious in that, as a general rule, some starting material was always recovered from the reaction mixture regardless of the stoichiometry of the reagents used. This unreacted olefin could be removed by treating the crude reaction mixture with palladium (II) salts (palladium trifluoroacetate, tetrabutylammonium chloride in acetone/water). Yields of the cyclopropane product (III) resulting from this 2-step sequence ranged between 50 and 90%. This diol ester was converted, uneventfully, to the monomethyl amide (IV) (CH3NH2, NH4Cl, 77%) and the linker attached under standard conditions (Cl(CH2)3Br, DMF, K2CO3) (V). This reaction proved to be nonselective and low yielding (approx. 45% yield). Methylation (dimethyl sufate, KOH, THF) followed by Finkelstein reaction (NaI, MEK) provided the key Western fragment (VI) in approximately 10% overall yield from methyl 2,4-dihydroxybenzoate.
| 【1】 Smith, P.F.; Paulson, S.K.; Tsai, B.S.; Fretland, D.J.; Dygos, J.H.; Yu, S.S.; Djuric, S.W.; SC-53228. Drugs Fut 1994, 19, 12, 1093. |
| 【2】 Yu, S.; Docter, S.; Djuric, S.; et al.; Synthesis and pharmacological activity of SC-53228, a leukotriene B4 receptor antagonist with high intrinsic potency and selectivity. Bioorg Med Chem Lett 1994, 4, 6, 811-6. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| 11463 | 3-Bromo-1-propene; 3-Bromopropene；allyl bromide | 106-95-6 | C3H5Br | 详情 | 详情 | |
| (I) | 16623 | methyl 2,4-dihydroxybenzoate | 2150-47-2 | C8H8O4 | 详情 | 详情 |
| (II) | 16624 | methyl 3-allyl-2,4-dihydroxybenzoate | C11H12O4 | 详情 | 详情 | |
| (III) | 16625 | methyl 3-(cyclopropylmethyl)-2,4-dihydroxybenzoate | C12H14O4 | 详情 | 详情 | |
| (IV) | 16626 | 3-(cyclopropylmethyl)-2,4-dihydroxy-N-methylbenzamide | C12H15NO3 | 详情 | 详情 | |
| (V) | 16627 | 4-(3-chloropropoxy)-3-(cyclopropylmethyl)-2-hydroxy-N-methylbenzamide | C15H20ClNO3 | 详情 | 详情 | |
| (VI) | 16628 | 3-(cyclopropylmethyl)-4-(3-iodopropoxy)-2-methoxy-N-methylbenzamide | C16H22INO3 | 详情 | 详情 |
合成路线2
该中间体在本合成路线中的序号：(VIII)1) 2-Aminobenzyl alcohol (I) was condensed with N-tert-butoxycarbonyl-4-piperidone (II) in toluene with azeotropical removal of water, and the resulting imine (III) was reduced with sodium cyanoborohydride to yield the secondary amine (IV). Further treatment of (IV) with triphosgene in the presence of N,N-diisopropyl ethylamine (DIEA) produced the benzoxazinone (V), which was then deprotected with HCl in EtOAc to give piperidine (VI).
| 【1】 Development of orally active oxytocin antagonists: Studies on 1-(1-[4-[1-(2-methyl-1-oxidopyridin-3-ylmethyl)piperidin-4-yloxy]-2-methoxybenzoyl]piperidin-4-yl)-1, 4-dihydrobenz[d][1,3]oxazin-2-one (L-372,662) and related pyridines. J Med Chem 1998, 41, 12, 2146. |
| 【2】 Bock, M.G.; Evans, B.E.; Hobbs, D.W.; Williams, P.D.; Anderson, P.S.; Freidinger, R.M.; Pettibone, D.J. (Merck & Co., Inc.); Benzoxazinone and benzopyrimidinone piperidinyl tocolytic oxytocin receptor antagonists. EP 0714299; JP 1997500134; US 5665719; WO 9502405 . |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 18619 | (2-aminophenyl)methanol; 2-Amino-benzenemethanol；2-Hydroxymethyl aniline;2-aminobenzyl alcohol;o-Aminobenzyl 2-aminobenzylalcohol;alcohol; 2-aminobenzenemethanol; 2-aminobenzyl alcohol | 5344-90-1 | C7H9NO | 详情 | 详情 |
| (II) | 18620 | tert-butyl 4-oxo-1-piperidinecarboxylate;BOC-Piperidone;N-(tert-Butoxycarbonyl)-4-piperidone; N-Boc-4-piperidone | 79099-07-3 | C10H17NO3 | 详情 | 详情 |
| (III) | 19417 | tert-butyl 4-[[2-(hydroxymethyl)phenyl]imino]-1-piperidinecarboxylate | C17H24N2O3 | 详情 | 详情 | |
| (IV) | 18621 | tert-butyl 4-[2-(hydroxymethyl)anilino]-1-piperidinecarboxylate | C17H26N2O3 | 详情 | 详情 | |
| (V) | 18622 | tert-butyl 4-[2-oxo-2H-3,1-benzoxazin-1(4H)-yl]-1-piperidinecarboxylate | C18H24N2O4 | 详情 | 详情 | |
| (VI) | 19420 | 1-(4-piperidinyl)-1,4-dihydro-2H-3,1-benzoxazin-2-one | C13H16N2O2 | 详情 | 详情 | |
| (VII) | 18625 | tert-butyl 4-hydroxy-1-piperidinecarboxylate | C10H19NO3 | 详情 | 详情 | |
| (VIII) | 16623 | methyl 2,4-dihydroxybenzoate | 2150-47-2 | C8H8O4 | 详情 | 详情 |
| (IX) | 19423 | tert-butyl 4-[3-hydroxy-4-(methoxycarbonyl)phenoxy]-1-piperidinecarboxylate | C18H25NO6 | 详情 | 详情 | |
| (X) | 18627 | tert-butyl 4-[3-methoxy-4-(methoxycarbonyl)phenoxy]-1-piperidinecarboxylate | C19H27NO6 | 详情 | 详情 | |
| (XI) | 18628 | 4-[[1-(tert-butoxycarbonyl)-4-piperidinyl]oxy]-2-methoxybenzoic acid | C18H25NO6 | 详情 | 详情 |
合成路线3
该中间体在本合成路线中的序号：(VI)Condensation of 2-(hydroxymethyl)aniline (I) with N-Boc-4-piperidone (II), followed by reduction with NaBH3CN provided anilinopiperidine (III). Cyclization of aminoalcohol (III) with triphosgene gave benzoxazinone (IV), which was deprotected by acidic treatment to yield piperidinylbenzoxazinone (V). Methyl 2,4-dihydroxybenzoate (VI) was selectively alkylated on the 4-position by coupling with N-Boc-4-piperidinol (VII) under Mitsunobu conditions to give ether (VIII). Then, the remaining 2-OH group was methylated with MeI and NaH to give (IX), which was saponified to provide the benzoic acid derivative (X). Coupling of amine (V) and acid (X) using EDC and HOBt produced amide (XI). Then, removal of the tert-butoxycarbonyl group by acid treatment, followed by acetylation of the resulting piperidine (XII) with Ac2O, furnished the target compound.
| 【1】 Williams, P.D.; et al.; 1-[1-[4-[(N-Acetyl-4-piperidinyl)oxy]-2-methoxybenzoyl]piperidin-4-yl]-4H-3,1-benzoxazin-2(1H)-one (L-371, 257): A new, orally bioavailable, non-peptide oxytocin antagonist. J Med Chem 1995, 38, 23, 4634. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 18619 | (2-aminophenyl)methanol; 2-Amino-benzenemethanol；2-Hydroxymethyl aniline;2-aminobenzyl alcohol;o-Aminobenzyl 2-aminobenzylalcohol;alcohol; 2-aminobenzenemethanol; 2-aminobenzyl alcohol | 5344-90-1 | C7H9NO | 详情 | 详情 |
| (II) | 18620 | tert-butyl 4-oxo-1-piperidinecarboxylate;BOC-Piperidone;N-(tert-Butoxycarbonyl)-4-piperidone; N-Boc-4-piperidone | 79099-07-3 | C10H17NO3 | 详情 | 详情 |
| (III) | 18621 | tert-butyl 4-[2-(hydroxymethyl)anilino]-1-piperidinecarboxylate | C17H26N2O3 | 详情 | 详情 | |
| (IV) | 18622 | tert-butyl 4-[2-oxo-2H-3,1-benzoxazin-1(4H)-yl]-1-piperidinecarboxylate | C18H24N2O4 | 详情 | 详情 | |
| (V) | 18623 | 1-(4-piperidinyl)-1,4-dihydro-2H-3,1-benzoxazin-2-one hydrochloride | C13H17ClN2O2 | 详情 | 详情 | |
| (VI) | 16623 | methyl 2,4-dihydroxybenzoate | 2150-47-2 | C8H8O4 | 详情 | 详情 |
| (VII) | 18625 | tert-butyl 4-hydroxy-1-piperidinecarboxylate | C10H19NO3 | 详情 | 详情 | |
| (VIII) | 19423 | tert-butyl 4-[3-hydroxy-4-(methoxycarbonyl)phenoxy]-1-piperidinecarboxylate | C18H25NO6 | 详情 | 详情 | |
| (IX) | 18627 | tert-butyl 4-[3-methoxy-4-(methoxycarbonyl)phenoxy]-1-piperidinecarboxylate | C19H27NO6 | 详情 | 详情 | |
| (X) | 18628 | 4-[[1-(tert-butoxycarbonyl)-4-piperidinyl]oxy]-2-methoxybenzoic acid | C18H25NO6 | 详情 | 详情 | |
| (XI) | 18629 | tert-butyl 4-[3-methoxy-4-([4-[2-oxo-2H-3,1-benzoxazin-1(4H)-yl]-1-piperidinyl]carbonyl)phenoxy]-1-piperidinecarboxylate | C31H39N3O7 | 详情 | 详情 | |
| (XII) | 18630 | 1-[1-[2-methoxy-4-(4-piperidinyloxy)benzoyl]-4-piperidinyl]-1,4-dihydro-2H-3,1-benzoxazin-2-one hydrochloride | C26H32ClN3O5 | 详情 | 详情 |
合成路线4
该中间体在本合成路线中的序号：(VII)Methyl 2,4-dihydroxybenzoate (VII) was selectively protected as the 4-benzyl ether (VIII) with benzyl bromide in the presence of potassium carbonate. Condensation with sodium (methylsulfinyl)methyde provided the corresponding methylsulfinyl ketone (IX). This was condensed with two equivalents of formaldehyde to yield (X). Subsequent pyrolysis of the sulfoxide group furnished chromenone (XI). Deprotection of the benzyl ether was achieved by treatment with boron trichloride, and the resulting 7-hydroxychromenone (XII) was then alkylated with 1-bromo-3-chloropropane (II) to give 7-(3-chloropropoxy)-3-(hydroxymethyl)-4H-chromen-4-one (V).
| 【1】 Nieto, J.; Bolos, J.; Unpublished results . |
| 【2】 Princep, M.; Guglietta, A.; Bolos, J.; Abaperidone Hydrochloride. Drugs Fut 2001, 26, 4, 335. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (II) | 10358 | 1-Bromo-3-chloropropane | 109-70-6 | C3H6BrCl | 详情 | 详情 |
| (V) | 26822 | 7-(3-chloropropoxy)-3-(hydroxymethyl)-4H-chromen-4-one | C13H13ClO4 | 详情 | 详情 | |
| (VII) | 16623 | methyl 2,4-dihydroxybenzoate | 2150-47-2 | C8H8O4 | 详情 | 详情 |
| (VIII) | 46606 | methyl 4-(benzyloxy)-2-hydroxybenzoate | C15H14O4 | 详情 | 详情 | |
| (IX) | 46607 | 1-[4-(benzyloxy)-2-hydroxyphenyl]-2-(methylsulfinyl)-1-ethanone | C16H16O4S | 详情 | 详情 | |
| (X) | 46608 | 7-(benzyloxy)-3-(hydroxymethyl)-3-(methylsulfinyl)-2,3-dihydro-4H-chromen-4-one | C18H18O5S | 详情 | 详情 | |
| (XI) | 46609 | 7-(benzyloxy)-3-(hydroxymethyl)-4H-chromen-4-one | C17H14O4 | 详情 | 详情 | |
| (XII) | 46610 | 7-hydroxy-3-(hydroxymethyl)-4H-chromen-4-one | C10H8O4 | 详情 | 详情 |