|
【结 构 式】 
|
【分子编号】13035 【品名】N,N,N-Trimethylamine; Trimethyl amine; N,N-Dimethylmethanamine 【CA登记号】75-50-3 |
【 分 子 式 】C3H9N 【 分 子 量 】59.1112 【元素组成】C 60.96% H 15.35% N 23.7% |
与该中间体有关的原料药合成路线共 2 条
合成路线1
该中间体在本合成路线中的序号：(V)The reaction of tetrahydrofuran-2,2-dimethanol (I) with 1 mole of octadecyl bromide (II) by means of KOH in DMSO gives the monoether (III), which is finally condensed with 2-chloro-2-oxo-1,3,2-dioxaphospholane (IV) and triethylamine in benzene to afford the target compound.
| 【1】 Houlihan, W.J.; Lee, M.L. (Novartis AG; Novartis Deutschland GmbH); Substd. hydroxy-heterocyclyl-alkoxy-phosphinyloxy-trialkylaminium-hydroxide inner salt oxides, processes for their preparation and their use as pharmaceuticals. AU 8662038; EP 0213082; JP 1987051692 . |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 47573 | [2-(hydroxymethyl)tetrahydro-2-furanyl]methanol | C6H12O3 | 详情 | 详情 | |
| (II) | 28797 | 1-bromooctadecane | 112-89-0 | C18H37Br | 详情 | 详情 |
| (III) | 47574 | [2-[(octadecyloxy)methyl]tetrahydro-2-furanyl]methanol | C24H48O3 | 详情 | 详情 | |
| (IV) | 28083 | 2-chloro-1,3,2lambda(5)-dioxaphospholan-2-one | 6609-64-9 | C2H4ClO3P | 详情 | 详情 |
| (V) | 13035 | N,N,N-Trimethylamine; Trimethyl amine; N,N-Dimethylmethanamine | 75-50-3 | C3H9N | 详情 | 详情 |
合成路线2
该中间体在本合成路线中的序号：(IV)The reaction of 2'-deoxy-5-fluoro-3'-O-oleoyluridine (I) with 2-bromoethylphosphodichloridate (II) by means of lutidine in THF gives 2'-deoxy-5-fluoro-3'-O-oleoyluridine 5'-(2-bromoethyl)phosphate (III), which is then condensed with trimethylamine (IV) in toluene.
| 【1】 Hori, T.; Myokan, I.; Miyabara, S. (Toyama Chemical Co., Ltd.); Novel 5-fluro-2'-desoxyuridine derivs. and their salts, process for their preparation and antitumor compsns. containing them. CH 670091; DE 3535766; FR 2571374; GB 2166740; JP 1986171498; US 4684631; US 4740503 . |
| 【2】 Hoshi, A.; Prous, J.; Castaner, J.; T-506. Drugs Fut 1990, 15, 5, 467. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 13032 | (2R,3S,5R)-5-[5-fluoro-2,4-dioxo-3,4-dihydro-1(2H)-pyrimidinyl]-2-(hydroxymethyl)tetrahydro-3-furanyl (Z)-9-octadecenoate | C27H43FN2O6 | 详情 | 详情 | |
| (II) | 13033 | Dichlorophosphoric acid 2-bromoethyl ester | C2H4BrCl2O2P | 详情 | 详情 | |
| (III) | 13034 | (2-bromoethoxy)([(2R,3S,5R)-5-[5-fluoro-2,4-dioxo-3,4-dihydro-1(2H)-pyrimidinyl]-3-[(Z)-9-octadecenoyloxy]tetrahydro-2-furanyl]methoxy)oxophosphoranolate | C29H46BrFN2O9P | 详情 | 详情 | |
| (IV) | 13035 | N,N,N-Trimethylamine; Trimethyl amine; N,N-Dimethylmethanamine | 75-50-3 | C3H9N | 详情 | 详情 |
Extended Information