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【结 构 式】 
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【药物名称】SDZ-62-834zi, NSC-614383, CRC-8605, SRI-62-834 【化学名称】(±)-2-[Hydroxy[2-(octadecyloxymethyl)tetrahydrofuran-2-ylmethoxy]phosphinyloxy]-N,N,N-trimethylethylamminium hydroxyde,inner salt P-oxide 【CA登记号】113201-37-9 【 分 子 式 】C29H60NO6P 【 分 子 量 】549.77845 |
【开发单位】Novartis (Originator) 【药理作用】ONCOLYTIC DRUGS |
合成路线1
The reaction of tetrahydrofuran-2,2-dimethanol (I) with 1 mole of octadecyl bromide (II) by means of KOH in DMSO gives the monoether (III), which is finally condensed with 2-chloro-2-oxo-1,3,2-dioxaphospholane (IV) and triethylamine in benzene to afford the target compound.
| 【1】 Houlihan, W.J.; Lee, M.L. (Novartis AG; Novartis Deutschland GmbH); Substd. hydroxy-heterocyclyl-alkoxy-phosphinyloxy-trialkylaminium-hydroxide inner salt oxides, processes for their preparation and their use as pharmaceuticals. AU 8662038; EP 0213082; JP 1987051692 . |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 47573 | [2-(hydroxymethyl)tetrahydro-2-furanyl]methanol | C6H12O3 | 详情 | 详情 | |
| (II) | 28797 | 1-bromooctadecane | 112-89-0 | C18H37Br | 详情 | 详情 |
| (III) | 47574 | [2-[(octadecyloxy)methyl]tetrahydro-2-furanyl]methanol | C24H48O3 | 详情 | 详情 | |
| (IV) | 28083 | 2-chloro-1,3,2lambda(5)-dioxaphospholan-2-one | 6609-64-9 | C2H4ClO3P | 详情 | 详情 |
| (V) | 13035 | N,N,N-Trimethylamine; Trimethyl amine; N,N-Dimethylmethanamine | 75-50-3 | C3H9N | 详情 | 详情 |
Extended Information