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【结 构 式】 
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【分子编号】13034 【品名】(2-bromoethoxy)([(2R,3S,5R)-5-[5-fluoro-2,4-dioxo-3,4-dihydro-1(2H)-pyrimidinyl]-3-[(Z)-9-octadecenoyloxy]tetrahydro-2-furanyl]methoxy)oxophosphoranolate 【CA登记号】 |
【 分 子 式 】C29H46BrFN2O9P 【 分 子 量 】696.5684852 【元素组成】C 50% H 6.66% Br 11.47% F 2.73% N 4.02% O 20.67% P 4.45% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(III)The reaction of 2'-deoxy-5-fluoro-3'-O-oleoyluridine (I) with 2-bromoethylphosphodichloridate (II) by means of lutidine in THF gives 2'-deoxy-5-fluoro-3'-O-oleoyluridine 5'-(2-bromoethyl)phosphate (III), which is then condensed with trimethylamine (IV) in toluene.
| 【1】 Hori, T.; Myokan, I.; Miyabara, S. (Toyama Chemical Co., Ltd.); Novel 5-fluro-2'-desoxyuridine derivs. and their salts, process for their preparation and antitumor compsns. containing them. CH 670091; DE 3535766; FR 2571374; GB 2166740; JP 1986171498; US 4684631; US 4740503 . |
| 【2】 Hoshi, A.; Prous, J.; Castaner, J.; T-506. Drugs Fut 1990, 15, 5, 467. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 13032 | (2R,3S,5R)-5-[5-fluoro-2,4-dioxo-3,4-dihydro-1(2H)-pyrimidinyl]-2-(hydroxymethyl)tetrahydro-3-furanyl (Z)-9-octadecenoate | C27H43FN2O6 | 详情 | 详情 | |
| (II) | 13033 | Dichlorophosphoric acid 2-bromoethyl ester | C2H4BrCl2O2P | 详情 | 详情 | |
| (III) | 13034 | (2-bromoethoxy)([(2R,3S,5R)-5-[5-fluoro-2,4-dioxo-3,4-dihydro-1(2H)-pyrimidinyl]-3-[(Z)-9-octadecenoyloxy]tetrahydro-2-furanyl]methoxy)oxophosphoranolate | C29H46BrFN2O9P | 详情 | 详情 | |
| (IV) | 13035 | N,N,N-Trimethylamine; Trimethyl amine; N,N-Dimethylmethanamine | 75-50-3 | C3H9N | 详情 | 详情 |
Extended Information