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【结 构 式】 
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【分子编号】18845 【品名】Dess-Martin periodinane; 1,1,1-Triacetoxy-1,2-benziodoxol-3(1H)-one 【CA登记号】87413-09-0 |
【 分 子 式 】C13H13IO8 【 分 子 量 】424.14589 【元素组成】C 36.81% H 3.09% I 29.92% O 30.18% |
合成路线1
该中间体在本合成路线中的序号：(A)Photochemical singlet oxygen addition to the silyl furan (XVII) in the presence of the sensitizer rose Bengal under irradiation of a mercury lamp afforded lactone (XVIII). The isopropylidene ketal of (XVIII) was then hydrolyzed to give glycol (XIX). Methyl acetalization of the hemiacetal hydroxyl group of (XIX) with dimethyl sulfate under basic conditions provided (XX). This was treated with liquid ammonia in MeOH to obtain the desired gamma-lactam (XXI) together with a small amount of lactone (XIX) that was separated by column chromatography. Methyl acetal reintroduction in (XXI) with MeOH in the presence of camphorsulfonic acid gave (XXII). Finally, oxidation of the secondary hydroxyl of (XXII) group with Dess-Martin periodinane furnished the title compound, existing as a 1:1 mixture of diastereomeric acetals.
| 【1】 Shiraki, R.; et al.; Total synthesis of PI-091. Tetrahedron Lett 1995, 36, 31, 5551. |
| 【2】 Shiraki, R.; et al.; Total synthesis of natural PI-091, a new platelet aggregation inhibitor of microbial origin. J Org Chem 1996, 61, 8, 2845. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (A) | 18845 | Dess-Martin periodinane; 1,1,1-Triacetoxy-1,2-benziodoxol-3(1H)-one | 87413-09-0 | C13H13IO8 | 详情 | 详情 |
| (XVII) | 26147 | [3-[(4R,5S)-5-hexyl-2,2,5-trimethyl-1,3-dioxolan-4-yl]-5-isopropyl-2-furyl](trimethyl)silane | C22H40O3Si | 详情 | 详情 | |
| (XVIII) | 26148 | 3-[(4R,5S)-5-hexyl-2,2,5-trimethyl-1,3-dioxolan-4-yl]-5-hydroxy-5-isopropyl-2(5H)-furanone | C19H32O5 | 详情 | 详情 | |
| (XIX) | 26149 | 3-[(1R,2S)-1,2-dihydroxy-2-methyloctyl]-5-hydroxy-5-isopropyl-2(5H)-furanone | C16H28O5 | 详情 | 详情 | |
| (XX) | 26150 | 3-[(1R,2S)-1,2-dihydroxy-2-methyloctyl]-5-isopropyl-5-methoxy-2(5H)-furanone | C17H30O5 | 详情 | 详情 | |
| (XXI) | 26151 | 3-[(1R,2S)-1,2-dihydroxy-2-methyloctyl]-5-hydroxy-5-isopropyl-1,5-dihydro-2H-pyrrol-2-one | C16H29NO4 | 详情 | 详情 | |
| (XXII) | 26152 | 3-[(1R,2S)-1,2-dihydroxy-2-methyloctyl]-5-isopropyl-1,5-dihydro-2H-pyrrol-2-one | C16H29NO3 | 详情 | 详情 |
合成路线2
该中间体在本合成路线中的序号：(A)The preparation of the precursor amino acids is shown in Schemes 1-4. Ozonolysis of (R)-citronellol (I), followed by Wittig reaction of the resulting aldehyde (II) with methylene triphenylphosphorane gave heptenol (III). Subsequent hydrogenation of (III) over Pd/C provided the saturated alcohol (IV), which was oxidized to the corresponding aldehyde (V) by treatment with Dess-Martin reagent. Asymmetric Strecker reaction in (V) utilizing (R)-phenylglycinol (VI) and trimethylsilyl cyanide afforded a diastereomeric mixture of aminonitriles (VII). After oxidative cleavage of (VII) with lead tetraacetate, the free (2S)-amine (VIII) was separated from its minor diastereomer by column chromatography. Acid hydrolysis of the nitrile group of (VIII) gave 5-propyl-L-leucine (IX), which was protected as the tert-butyl carbamate (X) with Boc2O.
| 【1】 Boger, D.L.; et al.; Total synthesis of HUN-7293. J Am Chem Soc 1999, 121, 26, 6197. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| 27301 | methylene(triphenyl)phosphorane | C19H17P | 详情 | 详情 | ||
| (A) | 18845 | Dess-Martin periodinane; 1,1,1-Triacetoxy-1,2-benziodoxol-3(1H)-one | 87413-09-0 | C13H13IO8 | 详情 | 详情 |
| (I) | 26264 | (3R)-3,7-dimethyl-6-octen-1-ol | 1117-61-9 | C10H20O | 详情 | 详情 |
| (II) | 26265 | (4R)-6-hydroxy-4-methylhexanal | C7H14O2 | 详情 | 详情 | |
| (III) | 26266 | (3R)-3-methyl-6-hepten-1-ol | C8H16O | 详情 | 详情 | |
| (IV) | 26267 | (3R)-3-methyl-1-heptanol | C8H18O | 详情 | 详情 | |
| (V) | 26268 | (3R)-3-methylheptanal | C8H16O | 详情 | 详情 | |
| (VI) | 14376 | (2R)-2-amino-2-phenyl-1-ethanol; (R)-(-)-2-phenylglycinol; (R)-2-amino-2-phenyl-1-ethanol | 56613-80-0 | C8H11NO | 详情 | 详情 |
| (VII) | 26269 | (4R)-2-[[(1R)-2-hydroxy-1-phenylethyl]amino]-4-methyloctanenitrile | C17H26N2O | 详情 | 详情 | |
| (VIII) | 26270 | (2S,4R)-2-amino-4-methyloctanenitrile | C9H18N2 | 详情 | 详情 | |
| (IX) | 26271 | (2S,4R)-2-amino-4-methyloctanoic acid | C9H19NO2 | 详情 | 详情 | |
| (X) | 26272 | (2S,4R)-2-[(tert-butoxycarbonyl)amino]-4-methyloctanoic acid | C14H27NO4 | 详情 | 详情 |
合成路线3
该中间体在本合成路线中的序号：(XIX)Title compound has been prepared by several related ways. Alkylation of methyl acetoacetate (I) with n-heptyl bromide (II) in the presence of NaOMe in refluxing MeOH yielded (III), which was brominated in CHCl3 at 0 C to give (IV). Subsequent reaction with triphenylmethyl mercaptan (V) and tetrabutyl ammonium hydroxide in toluene at r.t. provided (XI). Alternatively, beta-ketoester (XI) was prepared from a-mercaptoacetic acid (VI). Thus, protection as the S-trityl compound (VIII) by treatment with triphenylcarbinol (VII) and TFA, followed by condensation with N,O-dimethyl hydroxylamine in the presence of EDC and HOBt afforded N-methoxyamide (IX). Then, Claisen condensation with methyl nonanoate (X) using LDA as the base in THF at -78 C provided ketoester (XI). In order to avoid b-ketoacid decarboxylation, ketone (XI) was reduced to alcohol (XV) with NaBH4 in MeOH at 0 C. This hydroxyester was also prepared by a related route, consisting of protection of methyl mercaptoacetate (XII) as the S-trityl compound (XIII), followed by reduction to aldehyde (XIV) with DIBAL-H and condensation with methyl nonanoate (X). Saponification of methyl ester (XV) with KOH yielded hydroxyacid (XVI). Subsequent coupling with tert-butylglycine amide (XVII) using EDC and HOBt as the condensing agents produced amide (XVIII). Ketoamide (XX) was then obtained by oxidation with Dess-Martin periodinane (XIX). Finally, deprotection of the S-trityl group was effected by trifluoroacetic acid treatment under reducing conditions with triethyl silane to provide the target compound.
| 【1】 Campbell, D.A.; Xiao, X.Y.; Harris, D.; Ida, S.; Mortezaei, R.; Ngu, K.; Shi, L.; Tien, D.; Wang, Y.; Navre, M.; Patel, D.V.; Sharr, M.A.; DiJoseph, J.F.; Killar, L.M.; Leone, C.L.; Levin, J.I.; Skotnicki, J.S.; Malonyl alpha-mercaptoketones and alpha-mercaptoalcohols, a new class of matrix metalloproteinase inhibitors. Bioorg Med Chem Lett 1998, 8, 10, 1157. |
| 【2】 Campbell, D.A.; Patel, D.V.; Xiao, X.Y. (Affymax Technologies, NV); Novel inhibitors of collagenase-1 and stromelysin-I metalloproteases, pharmaceutical compsns. comprising same and methods of their use. WO 9640204 . |
| 【3】 Campbell, D.A.; Patel, D.V.; Xiao, X.Y. (Affymax Technologies, NV); Novel inhibitors of metalloproteases, pharmaceutical compsns. comprising same and methods of their use. WO 9640738 . |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 11791 | methyl 3-oxobutanoate; Methyl acetoacetate | 105-45-3 | C5H8O3 | 详情 | 详情 |
| (II) | 18828 | 1-bromoheptane | 629-04-9 | C7H15Br | 详情 | 详情 |
| (III) | 18829 | methyl 2-acetylnonanoate | C12H22O3 | 详情 | 详情 | |
| (IV) | 18830 | methyl 2-(2-bromoacetyl)nonanoate | C12H21BrO3 | 详情 | 详情 | |
| (V) | 18831 | tritylhydrosulfide; triphenylmethanethiol | 3695-77-0 | C19H16S | 详情 | 详情 |
| (VI) | 18524 | 2-sulfanylacetic acid | 68-11-1 | C2H4O2S | 详情 | 详情 |
| (VII) | 18833 | Trityl alcohol; triphenylmethanol | 76-84-6 | C19H16O | 详情 | 详情 |
| (VIII) | 18834 | 2-(tritylsulfanyl)acetic acid | C21H18O2S | 详情 | 详情 | |
| (IX) | 18835 | N-methoxy-N-methyl-2-(tritylsulfanyl)acetamide | C23H23NO2S | 详情 | 详情 | |
| (X) | 18836 | methyl nonanoate | 1731-84-6 | C10H20O2 | 详情 | 详情 |
| (XI) | 18837 | methyl 2-[2-(tritylsulfanyl)acetyl]nonanoate | C31H36O3S | 详情 | 详情 | |
| (XII) | 18838 | methyl 2-sulfanylacetate | 2365-48-2 | C3H6O2S | 详情 | 详情 |
| (XIII) | 18839 | methyl 2-(tritylsulfanyl)acetate | C22H20O2S | 详情 | 详情 | |
| (XIV) | 18840 | 2-(tritylsulfanyl)acetaldehyde | C21H18OS | 详情 | 详情 | |
| (XV) | 18841 | methyl 2-[1-hydroxy-2-(tritylsulfanyl)ethyl]nonanoate | C31H38O3S | 详情 | 详情 | |
| (XVI) | 18842 | 2-[1-hydroxy-2-(tritylsulfanyl)ethyl]nonanoic acid | C30H36O3S | 详情 | 详情 | |
| (XVII) | 18843 | (2S)-2-amino-N,3,3-trimethylbutanamide | 89226-12-0 | C7H16N2O | 详情 | 详情 |
| (XVIII) | 18844 | N-[(1S)-2,2-dimethyl-1-[(methylamino)carbonyl]propyl]-2-[1-hydroxy-2-(tritylsulfanyl)ethyl]nonanamide | C37H50N2O3S | 详情 | 详情 | |
| (XIX) | 18845 | Dess-Martin periodinane; 1,1,1-Triacetoxy-1,2-benziodoxol-3(1H)-one | 87413-09-0 | C13H13IO8 | 详情 | 详情 |
| (XX) | 18846 | N-[(1S)-2,2-dimethyl-1-[(methylamino)carbonyl]propyl]-2-[2-(tritylsulfanyl)acetyl]nonanamide | C37H48N2O3S | 详情 | 详情 |
合成路线4
该中间体在本合成路线中的序号：(X)L-DOPA (I) was esterified by means of MeOH and SOCl2, and the resulting aminoester (II) was protected with benzyloxycarbonyloxy succinimide to give carbamate (III). Further reaction of (III) with 1,2-dibromoethane produced the cyclic diether derivative (IV). Chlorsulfonylation of (IV), followed by basic treatment with DMAP and Et3N gave rise to the benzothiazine (V). After N-alkylation of (V) with iodoethane and K2CO3, basic hydrolysis of the resulting methyl ester (VI) provided carboxylic acid (VII). This was coupled to L-phenylalaninol (VIII) using benzotriazol-1-yloxy-tris(dimethylamino)phosphonium hexafluorophosphate (BOP) and 1-hydroxybenzotriazole (HOBt) to afford the corresponding amide as a diastereomeric mixture, which was separated by flash chromatography. The required (S,S)-diastereoisomer (IX) was then oxidized to the title aldehyde using Dess-Martin periodinane reagent.
| 【1】 Wells, G.J.; et al.; 1,2-Benzothiazine 1,1-dioxide P2-P3 peptide mimetic aldehyde calpain I inhibitors. J Med Chem 2001, 44, 21, 3488. |
| 【2】 Bihovsky, R.; Wells, G.J.; Tao, M. (Cephalon, Inc.); Benzothiazo and related heterocyclic group-containing cysteine and serine protease. WO 9821186 . |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 15272 | (2S)-2-amino-3-(3,4-dihydroxyphenyl)propionic acid; 3-hydroxy-L-tyrosine; Levodopa | 59-92-7 | C9H11NO4 | 详情 | 详情 |
| (II) | 29568 | methyl (2S)-2-amino-3-(3,4-dihydroxyphenyl)propanoate | C10H13NO4 | 详情 | 详情 | |
| (III) | 29569 | methyl (2S)-2-[[(benzyloxy)carbonyl]amino]-3-(3,4-dihydroxyphenyl)propanoate | C18H19NO6 | 详情 | 详情 | |
| (IV) | 29570 | methyl (2S)-2-[[(benzyloxy)carbonyl]amino]-3-(2,3-dihydro-1,4-benzodioxin-6-yl)propanoate | C20H21NO6 | 详情 | 详情 | |
| (V) | 29571 | methyl 1,1-dioxo-1,2,3,4,7,8-hexahydro-2H-[1,4]dioxino[2,3-g][1,2]benzothiazine-3-carboxylate | C12H13NO6S | 详情 | 详情 | |
| (VI) | 29572 | methyl 2-ethyl-1,1-dioxo-1,2,3,4,7,8-hexahydro-2H-[1,4]dioxino[2,3-g][1,2]benzothiazine-3-carboxylate | C14H17NO6S | 详情 | 详情 | |
| (VII) | 29573 | 2-ethyl-1,1-dioxo-1,2,3,4,7,8-hexahydro-2H-[1,4]dioxino[2,3-g][1,2]benzothiazine-3-carboxylic acid | C13H15NO6S | 详情 | 详情 | |
| (VIII) | 28523 | (2S)-2-amino-3-phenyl-1-propanol; L-phenylalanilol; (S)-2-amino-3-phenyl-1-propanol | 5267-64-1 | C9H13NO | 详情 | 详情 |
| (IX) | 29574 | (3S)-N-[(1S)-1-benzyl-2-hydroxyethyl]-2-ethyl-1,1-dioxo-1,2,3,4,7,8-hexahydro-2H-[1,4]dioxino[2,3-g][1,2]benzothiazine-3-carboxamide | C22H26N2O6S | 详情 | 详情 | |
| (X) | 18845 | Dess-Martin periodinane; 1,1,1-Triacetoxy-1,2-benziodoxol-3(1H)-one | 87413-09-0 | C13H13IO8 | 详情 | 详情 |
合成路线5
该中间体在本合成路线中的序号：(XIII)The coupling of (X) with 5-methylisoxazole-3-carbonyl chloride (XI), yielded amide (XII). The alcohol group of (XII) was then oxidized to ketone (XIV) employing Dess-Martin periodinane (XIII). Finally, the 2,4-dimethoxybenzyl group (DMB) of (XIV) was cleaved by treatment with DDQ in hot acetonitrile.
| 【1】 Zhou, R.; Dragovich, P.S.; Webber, S.E.; et al.; Structure-based design of ketone-containing, tripeptidyl human rhinovirus 3C protease inhibitors. Bioorg Med Chem Lett 2000, 10, 1, 45. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (X) | 36600 | (2S)-2-amino-N-[(1S)-2-[((1S)-2-(1,3-benzothiazol-2-yl)-1-[[(3S)-1-(2,4-dimethoxybenzyl)-2-oxopyrrolidinyl]methyl]-2-hydroxyethyl)amino]-1-(4-fluorobenzyl)-2-oxoethyl]-3-methylbutanamide | C37H44FN5O6S | 详情 | 详情 | |
| (XI) | 32107 | 5-methyl-3-isoxazolecarbonyl chloride | C5H4ClNO2 | 详情 | 详情 | |
| (XII) | 36601 | N-[(1S)-1-([[(1S)-2-[((1S)-2-(1,3-benzothiazol-2-yl)-1-[[(3S)-1-(2,4-dimethoxybenzyl)-2-oxopyrrolidinyl]methyl]-2-hydroxyethyl)amino]-1-(4-fluorobenzyl)-2-oxoethyl]amino]carbonyl)-2-methylpropyl]-5-methyl-3-isoxazolecarboxamide | C42H47FN6O8S | 详情 | 详情 | |
| (XIII) | 18845 | Dess-Martin periodinane; 1,1,1-Triacetoxy-1,2-benziodoxol-3(1H)-one | 87413-09-0 | C13H13IO8 | 详情 | 详情 |
| (XIV) | 36602 | N-[(1S)-1-([[(1S)-2-[((1S)-2-(1,3-benzothiazol-2-yl)-1-[[(3S)-1-(2,4-dimethoxybenzyl)-2-oxopyrrolidinyl]methyl]-2-oxoethyl)amino]-1-(4-fluorobenzyl)-2-oxoethyl]amino]carbonyl)-2-methylpropyl]-5-methyl-3-isoxazolecarboxamide | C42H45FN6O8S | 详情 | 详情 |