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【结 构 式】

【药物名称】Conivaptan hydrochloride, CI-1025, YM-087

【化学名称】N-[4-(2-Methyl-1,4,5,6-tetrahydroimidazo[4,5-d][1]benzazepin-6-ylcarbonyl)phenyl]biphenyl-2-carboxamide hydrochloride

【CA登记号】168626-94-6, 210101-16-9 (free base)

【 分 子 式 】C32H27ClN4O2

【 分 子 量 】535.05059

【开发单位】Yamanouchi (Originator), Pfizer (Licensee)

【药理作用】CARDIOVASCULAR DRUGS, Diuretics, Heart Failure Therapy, RENAL-UROLOGIC DRUGS, Oxytocin Antagonists, Vasopressin V1a Antagonists, Vasopressin V2 Antagonists

合成路线1合成路线2合成路线3合成路线4合成路线5合成路线6

合成路线1

　

参考文献 中间体
【1】 MatsuhisaA，Taniguchi N,et al.2000.Nonpeptide arginine vasopressin antagonists for both VIA and V2 receptors: synthesis and pharmacological properties of 4'-(1,4,5,6-tetrahydroimidazo[4,5-d] [1] benzazepine-6-carbonyl) benzanilide derivatives and 4’-(5,6-dihydro-4H-thiazolo[5,4-d] [1] benzazepint-6-carbonyl) benzanilide derivative. Chem Pharm Bull, 48, 21～31 MatsuhisaA，Taniguchi N,et al.2000.Nonpeptide arginine vasopressin antagonists for both VIA and V2 receptors: synthesis and pharmacological properties of 4'-(1,4,5,6-tetrahydroimidazo[4,5-d] [1] benzazepine-6-carbonyl) benzanilide derivatives and 4’-(5,6-dihydro-4H-thiazolo[5,4-d] [1] benzazepint-6-carbonyl) benzanilide derivative. Chem Pharm Bull, 48, 21～31 MatsuhisaA，Taniguchi N,et al.2000.Nonpeptide arginine vasopressin antagonists for both VIA and V2 receptors: synthesis and pharmacological properties of 4'-(1,4,5,6-tetrahydroimidazo[4,5-d] [1] benzazepine-6-carbonyl) benzanilide derivatives and 4’-(5,6-dihydro-4H-thiazolo[5,4-d] [1] benzazepint-6-carbonyl) benzanilide derivative. Chem Pharm Bull, 48, 21～31
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
（V） 41814 N-[4-[(4-bromo-5-oxo-2,3,4,5-tetrahydro-1H-1-benzazepin-1-yl)carbonyl]phenyl][1,1'-biphenyl]-2-carboxamide C30H23BrN2O3 详情 详情
(I) 41811 1-(4-nitrobenzoyl)-1,2,3,4-tetrahydro-5H-1-benzazepin-5-one C17H14N2O4 详情 详情
(II) 41812 1-(4-aminobenzoyl)-1,2,3,4-tetrahydro-5H-1-benzazepin-5-one C17H16N2O2 详情 详情
(III) 18506 [1,1'-biphenyl]-2-carbonyl chloride C13H9ClO 详情 详情
(IV) 41813 N-[4-[(5-oxo-2,3,4,5-tetrahydro-1H-1-benzazepin-1-yl)carbonyl]phenyl][1,1'-biphenyl]-2-carboxamide C30H24N2O3 详情 详情
(VI) 66210 N-(4-(2-methyl-1,4,5,6-tetrahydrobenzo[b]imidazo[4,5-d]azepine-6-carbonyl)phenyl)-[1,1'-biphenyl]-2-carboxamide；Conivaptan 210101-16-9 C32H26N4O2 详情 详情

合成路线2

　

参考文献 中间体
【1】 Tsunoda T,Yamazaki A.et al.2003.vasopressin antagonist. Org Ptoc Res Dev,7 1 883~887 MatsuhisaA，Taniguchi N,et al.2000.Nonpeptide arginine vasopressin antagonists for both VIA and V2 receptors: synthesis and pharmacological properties of 4'-(1,4,5,6-tetrahydroimidazo[4,5-d] [1] benzazepine-6-carbonyl) benzanilide derivatives and 4’-(5,6-dihydro-4H-thiazolo[5,4-d] [1] benzazepint-6-carbonyl) benzanilide derivative. Chem Pharm Bull, 48, 21～31
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(I) 41811 1-(4-nitrobenzoyl)-1,2,3,4-tetrahydro-5H-1-benzazepin-5-one C17H14N2O4 详情 详情
(II) 66211 4-bromo-1-(4-nitrobenzoyl)-3,4-dihydro-1H-benzo[b]azepin-5(2H)-one 　 C17H13BrN2O4 详情 详情
(III) 41818 [2-methyl-4,5-dihydroimidazo[4,5-d][1]benzazepin-6(1H)-yl](4-nitrophenyl)methanone C19H16N4O3 详情 详情
(IV) 41819 (4-aminophenyl)[2-methyl-4,5-dihydroimidazo[4,5-d][1]benzazepin-6(1H)-yl]methanone C19H18N4O 详情 详情
(VII) 18506 [1,1'-biphenyl]-2-carbonyl chloride C13H9ClO 详情 详情

合成路线3

　

参考文献 中间体
【1】 Tsunoda T, Tanaka A, et al.2004.Anew synthetic route to YM087, an argirune asopressin antagonist.Heterocycles, 63: 1113---1122
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
（V） 14763 1-[(4-methylphenyl)sulfonyl]-1,2,3,4-tetrahydro-5H-1-benzazepin-5-one C17H17NO3S 详情 详情
(I) 11161 methyl 2-aminobenzoate; Methyl anthranilate 134-20-3 C8H9NO2 详情 详情
(II) 66212 methyl 2-(4-methylphenylsulfonamido)benzoate 　 C15H15NO4S 详情 详情
(III) 66213 methyl 2-(N-(3-cyanopropyl)-4-methylphenylsulfonamido)benzoate 　 C19H20N2O4S 详情 详情
(IV) 66214 4-ethynyl-1-tosyl-3,4-dihydro-1H-benzo[b]azepin-5(2H)-one 　 C19H17N2O3S 详情 详情
(VI) 41815 4-bromo-1-[(4-methylphenyl)sulfonyl]-1,2,3,4-tetrahydro-5H-1-benzazepin-5-one C17H16BrNO3S 详情 详情
(VII) 41816 2-methyl-6-[(4-methylphenyl)sulfonyl]-1,4,5,6-tetrahydroimidazo[4,5-d][1]benzazepine C19H19N3O2S 详情 详情
(VIII) 41817 2-methyl-1,4,5,6-tetrahydroimidazo[4,5-d][1]benzazepine 318237-73-9 C12H13N3 详情 详情
(IX) 41818 [2-methyl-4,5-dihydroimidazo[4,5-d][1]benzazepin-6(1H)-yl](4-nitrophenyl)methanone C19H16N4O3 详情 详情
(X) 41819 (4-aminophenyl)[2-methyl-4,5-dihydroimidazo[4,5-d][1]benzazepin-6(1H)-yl]methanone C19H18N4O 详情 详情
(XII) 18941 p-nitrobenzoyl chloride; 4-nitrobenzoyl chloride 122-04-3 C7H4ClNO3 详情 详情

合成路线4

Acylation of 2,3,4,5-tetrahydro-1H-1-benzazepin-5-one (I) with 4-nitrobenzoyl chloride (II) by means of TEA in CH2Cl2 gives 1-(4-nitrobenzoyl)-2,3,4,5-tetrahydro-1H-1-benzazepin-5-one (III), which is hydrogenated with H2 over Raney-Ni in MeOH, yielding the corresponding amine derivative (IV). Acylation of (IV) with biphenyl-2-carboxylic acid (V) by means of oxalyl chloride in CH2Cl2 affords the expected amide (VI) which is brominated with either Br2 or CuBr2, providing the alpha-bromo ketone (VII). This ketone (VII) is cyclized with acetamidine hydrochloride (VIII) by means of K2CO3 in MeCN, furnishing a mixture of conivaptan and oxazolo[4,5-d][1]benzodiazepine compound. Finally, conivaptan is separated by column chromatography over silica gel and is treated with 4N HCl to provide the desired hydrochloride.

参考文献 中间体
【1】 Castañer, R.M.; Norman, P.; Rabasseda, X.; Leeson, P.A.; Castañer, J.; Conivaptan Hydrochloride. Drugs Fut 2000, 25, 11, 1121.
【2】 Tanaka, A.; Koshio, H.; Taniguchi, N.; Matsuhisa, A.; Sakamoto, K.; Yamazaki, A.; Yatsu, T. (Yamanouchi Pharmaceutical Co., Ltd.); Fused benzazepine deriv. and pharmaceutical compsn. containing the same. EP 0709386; JP 1995505056; US 5723606; WO 9503305 .
【3】 Koshio, H.; Taniguchi, N.; Tanaka, A.; Yatsu, T.; Matsuhisa, A.; Nonpeptide arginine vasopressin antagonists for both V1A and V2 receptors: Synthesis and pharmacological properties of 4'-(1,4,5,6-tetrahydroimidazo[4,5-d][1]benzoazepine-6-carbonyl)benzanilide derivatives and 4'-(5,6-dihydro-4H-thiazolo[5,4-d][1]benzoaze. Chem Pharm Bull 2000, 48, 1, 21.
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(I) 41810 1,2,3,4-tetrahydro-5H-1-benzazepin-5-one C10H11NO 详情 详情
(II) 18941 p-nitrobenzoyl chloride; 4-nitrobenzoyl chloride 122-04-3 C7H4ClNO3 详情 详情
(III) 41811 1-(4-nitrobenzoyl)-1,2,3,4-tetrahydro-5H-1-benzazepin-5-one C17H14N2O4 详情 详情
(IV) 41812 1-(4-aminobenzoyl)-1,2,3,4-tetrahydro-5H-1-benzazepin-5-one C17H16N2O2 详情 详情
(V) 18505 [1,1'-biphenyl]-2-carboxylic acid 947-84-2 C13H10O2 详情 详情
(VI) 41813 N-[4-[(5-oxo-2,3,4,5-tetrahydro-1H-1-benzazepin-1-yl)carbonyl]phenyl][1,1'-biphenyl]-2-carboxamide C30H24N2O3 详情 详情
(VII) 41814 N-[4-[(4-bromo-5-oxo-2,3,4,5-tetrahydro-1H-1-benzazepin-1-yl)carbonyl]phenyl][1,1'-biphenyl]-2-carboxamide C30H23BrN2O3 详情 详情
(VIII) 15866 ethanimidamide C2H6N2 详情 详情

合成路线5

The bromination of 1-(p-toluenesulfonyl)-2,3,4,5-tetrahydro-1H-1-benzazepin-5-one (IX) with Br2 in CHCl3 gives the alpha-bromo ketone (X), which is cyclized with acetamidine hydrochloride (VIII) by means of K2CO3, yielding the expected imidazo-benzazepine (XI). This compound is detosylated with hot H2SO4 to provide 2-methyl-1,4,5,6-tetrahydroimidazo[4,5-d][1]benzazepine (XII). Acylation of (XII) with 4-nitroben-zoic acid (XIII) by means of pyridine in either hot MeCN or DMF affords the 6-(4-nitro-benzoyl) derivative (XIV), which is reduced with H2 and Raney-Ni in MeOH to the corres-ponding 6-(4-aminobenzoyl) compound (XV). Finally, this compound is condensed with biphenyl-2-carbonyl chloride (XVI) [ obtained by treatment of biphenyl-2-carboxylic acid (V) with oxalyl chloride in CH2Cl2/DMF] by means of pyridine in acetonitrile and treated with 4N HCl.

参考文献 中间体
【1】 Castañer, R.M.; Norman, P.; Rabasseda, X.; Leeson, P.A.; Castañer, J.; Conivaptan Hydrochloride. Drugs Fut 2000, 25, 11, 1121.
【2】 Yamazaki, A.; Tanaka, A.; Tsunoda, T. (Yamanouchi Pharmaceutical Co., Ltd.); Novel preparation method of condensed benzazepine derivs.. JP 1996198879 .
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(V) 18505 [1,1'-biphenyl]-2-carboxylic acid 947-84-2 C13H10O2 详情 详情
(VIII) 15866 ethanimidamide C2H6N2 详情 详情
(IX) 14763 1-[(4-methylphenyl)sulfonyl]-1,2,3,4-tetrahydro-5H-1-benzazepin-5-one C17H17NO3S 详情 详情
(X) 41815 4-bromo-1-[(4-methylphenyl)sulfonyl]-1,2,3,4-tetrahydro-5H-1-benzazepin-5-one C17H16BrNO3S 详情 详情
(XI) 41816 2-methyl-6-[(4-methylphenyl)sulfonyl]-1,4,5,6-tetrahydroimidazo[4,5-d][1]benzazepine C19H19N3O2S 详情 详情
(XII) 41817 2-methyl-1,4,5,6-tetrahydroimidazo[4,5-d][1]benzazepine 318237-73-9 C12H13N3 详情 详情
(XIII) 18119 4-nitrobenzoic acid; p-nitrobenzoic acid 62-23-7 C7H5NO4 详情 详情
(XIV) 41818 [2-methyl-4,5-dihydroimidazo[4,5-d][1]benzazepin-6(1H)-yl](4-nitrophenyl)methanone C19H16N4O3 详情 详情
(XV) 41819 (4-aminophenyl)[2-methyl-4,5-dihydroimidazo[4,5-d][1]benzazepin-6(1H)-yl]methanone C19H18N4O 详情 详情
(XVI) 18506 [1,1'-biphenyl]-2-carbonyl chloride C13H9ClO 详情 详情

合成路线6

Alternatively, treatment of biphenyl-2-carboxylic acid (V) with SOCl2 and DMF in CH2Cl2 provides the acyl chloride (XVI), which is condensed with 4-aminobenzoic acid (XVII) by means of N,N-dimethylaniline in acetone to give the corresponding 4-(2-phenylbenzamido)benzoic acid (XVIII). Treatment of (XVIII) with SOCl2 and DMF in dry THF affords the acyl chloride (XIX), which is finally condensed with the inmidazobenzazepine (XII) by means of pyridine in MeCN and treated with 4N HCl.

参考文献 中间体
【1】 Castañer, R.M.; Norman, P.; Rabasseda, X.; Leeson, P.A.; Castañer, J.; Conivaptan Hydrochloride. Drugs Fut 2000, 25, 11, 1121.
【2】 Yamazaki, A.; Tanaka, A.; Tsunoda, T. (Yamanouchi Pharmaceutical Co., Ltd.); Novel preparation method of condensed benzazepine derivs.. JP 1996198879 .
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(V) 18505 [1,1'-biphenyl]-2-carboxylic acid 947-84-2 C13H10O2 详情 详情
(XII) 41817 2-methyl-1,4,5,6-tetrahydroimidazo[4,5-d][1]benzazepine 318237-73-9 C12H13N3 详情 详情
(XVI) 18506 [1,1'-biphenyl]-2-carbonyl chloride C13H9ClO 详情 详情
(XVII) 20004 p-aminobenzoic acid; 4-aminobenzoic acid 150-13-0 C7H7NO2 详情 详情
(XVIII) 41820 4-[([1,1'-biphenyl]-2-ylcarbonyl)amino]benzoic acid C20H15NO3 详情 详情
(XIX) 36810 4-[([1,1'-biphenyl]-2-ylcarbonyl)amino]benzoyl chloride C20H14ClNO2 详情 详情
Extended Information
Drug NewChemical Entity Original Patent(1)