N-(4-(2-methyl-1,4,5,6-tetrahydrobenzo[b]imidazo[4,5-d]azepine-6-carbonyl)phenyl)-[1,1'-biphenyl]-2-carboxamide；Conivaptan -Drug Synthesis Database

【结构式】

【分子编号】66210

【品名】N-(4-(2-methyl-1,4,5,6-tetrahydrobenzo[b]imidazo[4,5-d]azepine-6-carbonyl)phenyl)-[1,1'-biphenyl]-2-carboxamide；Conivaptan

【CA登记号】210101-16-9

【分子式】C₃₂H₂₆N₄O₂

【分子量】498.584

【元素组成】C 77.09% H 5.26% N 11.24% O 6.42%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(VI)

【1】 MatsuhisaA，Taniguchi N,et al.2000.Nonpeptide arginine vasopressin antagonists for both VIA and V2 receptors: synthesis and pharmacological properties of 4'-(1,4,5,6-tetrahydroimidazo[4,5-d] [1] benzazepine-6-carbonyl) benzanilide derivatives and 4’-(5,6-dihydro-4H-thiazolo[5,4-d] [1] benzazepint-6-carbonyl) benzanilide derivative. Chem Pharm Bull, 48, 21～31 MatsuhisaA，Taniguchi N,et al.2000.Nonpeptide arginine vasopressin antagonists for both VIA and V2 receptors: synthesis and pharmacological properties of 4'-(1,4,5,6-tetrahydroimidazo[4,5-d] [1] benzazepine-6-carbonyl) benzanilide derivatives and 4’-(5,6-dihydro-4H-thiazolo[5,4-d] [1] benzazepint-6-carbonyl) benzanilide derivative. Chem Pharm Bull, 48, 21～31 MatsuhisaA，Taniguchi N,et al.2000.Nonpeptide arginine vasopressin antagonists for both VIA and V2 receptors: synthesis and pharmacological properties of 4'-(1,4,5,6-tetrahydroimidazo[4,5-d] [1] benzazepine-6-carbonyl) benzanilide derivatives and 4’-(5,6-dihydro-4H-thiazolo[5,4-d] [1] benzazepint-6-carbonyl) benzanilide derivative. Chem Pharm Bull, 48, 21～31

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
（V）	41814	N-[4-[(4-bromo-5-oxo-2,3,4,5-tetrahydro-1H-1-benzazepin-1-yl)carbonyl]phenyl][1,1'-biphenyl]-2-carboxamide		C₃₀H₂₃BrN₂O₃	详情	详情
(I)	41811	1-(4-nitrobenzoyl)-1,2,3,4-tetrahydro-5H-1-benzazepin-5-one		C₁₇H₁₄N₂O₄	详情	详情
(II)	41812	1-(4-aminobenzoyl)-1,2,3,4-tetrahydro-5H-1-benzazepin-5-one		C₁₇H₁₆N₂O₂	详情	详情
(III)	18506	[1,1'-biphenyl]-2-carbonyl chloride		C₁₃H₉ClO	详情	详情
(IV)	41813	N-[4-[(5-oxo-2,3,4,5-tetrahydro-1H-1-benzazepin-1-yl)carbonyl]phenyl][1,1'-biphenyl]-2-carboxamide		C₃₀H₂₄N₂O₃	详情	详情
(VI)	66210	N-(4-(2-methyl-1,4,5,6-tetrahydrobenzo[b]imidazo[4,5-d]azepine-6-carbonyl)phenyl)-[1,1'-biphenyl]-2-carboxamide；Conivaptan	210101-16-9	C₃₂H₂₆N₄O₂	详情	详情

Extended Information