4-[([1,1'-biphenyl]-2-ylcarbonyl)amino]benzoic acid -Drug Synthesis Database

【结构式】

【分子编号】41820

【品名】4-[([1,1'-biphenyl]-2-ylcarbonyl)amino]benzoic acid

【CA登记号】

【分子式】C₂₀H₁₅NO₃

【分子量】317.34404

【元素组成】C 75.7% H 4.76% N 4.41% O 15.12%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(XVIII)

Alternatively, treatment of biphenyl-2-carboxylic acid (V) with SOCl2 and DMF in CH2Cl2 provides the acyl chloride (XVI), which is condensed with 4-aminobenzoic acid (XVII) by means of N,N-dimethylaniline in acetone to give the corresponding 4-(2-phenylbenzamido)benzoic acid (XVIII). Treatment of (XVIII) with SOCl2 and DMF in dry THF affords the acyl chloride (XIX), which is finally condensed with the inmidazobenzazepine (XII) by means of pyridine in MeCN and treated with 4N HCl.

参考文献中间体

合成目标

【1】 Castañer, R.M.; Norman, P.; Rabasseda, X.; Leeson, P.A.; Castañer, J.; Conivaptan Hydrochloride. Drugs Fut 2000, 25, 11, 1121.
【2】 Yamazaki, A.; Tanaka, A.; Tsunoda, T. (Yamanouchi Pharmaceutical Co., Ltd.); Novel preparation method of condensed benzazepine derivs.. JP 1996198879 .

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(V)	18505	[1,1'-biphenyl]-2-carboxylic acid	947-84-2	C₁₃H₁₀O₂	详情	详情
(XII)	41817	2-methyl-1,4,5,6-tetrahydroimidazo[4,5-d][1]benzazepine	318237-73-9	C₁₂H₁₃N₃	详情	详情
(XVI)	18506	[1,1'-biphenyl]-2-carbonyl chloride		C₁₃H₉ClO	详情	详情
(XVII)	20004	p-aminobenzoic acid; 4-aminobenzoic acid	150-13-0	C₇H₇NO₂	详情	详情
(XVIII)	41820	4-[([1,1'-biphenyl]-2-ylcarbonyl)amino]benzoic acid		C₂₀H₁₅NO₃	详情	详情
(XIX)	36810	4-[([1,1'-biphenyl]-2-ylcarbonyl)amino]benzoyl chloride		C₂₀H₁₄ClNO₂	详情	详情

Extended Information