【结 构 式】 |
【分子编号】69619 【品名】(Z)-S-benzo[d]thiazol-2-yl 2-(2-aminothiazol-4-yl)-2-((trityloxy)imino)ethanethioate 【CA登记号】 |
【 分 子 式 】 C31H22N4O2S3 【 分 子 量 】578.739 【元素组成】C 64.34% H 3.83% N 9.68% O 5.53% S 16.62% |
与该中间体有关的原料药合成路线共 3 条
合成路线1
该中间体在本合成路线中的序号:(IX)
【1】 Huwiler A,Teund L.Production of 2-(2-aminothiazole-4-yl)-2- (syn)-methoxyimino acetic esters:EP,Patent 45,005,1982. |
【2】 胡艾希,徐娟娟,伍小云.氨噻肟酸乙酯的合成.中国医药工业杂 志.2206,37.229 |
【3】 程清蓉,刘志雄,李翔,等.去甲氨噻肟酸乙酯的合成研究.化学世界,2007,48:480 |
【4】 郑庚修,李贺,赵叶青.制备去甲氨噻肟酸乙酯的方法:CN,Patent 101,007,793,2007. |
【5】 Defossa E,Fischer G,Gerlach U,et al.Synthesis of HR 916 K.Am efficient route to the pure diastereomers of the 1-(pivaloyloxy)ethyl esters of cephalosporins.Liebigs Annalen,1996,(11):1743. |
【6】 Yamanaka H,Chiba T,Kawabata K,et al.Studies on β-lactam antibiotics.IX.Synthesis and biological activity of new orally active cephalosporin,cefixime(FK027).J Antibiotics,1985,38:1738. |
【7】 Takaya T,Takasugi H,Masugi T,et al.7-Acylamino-3-substituted cephalosporanic acid derivatives,processes for their preparation and pharmaceutical compositions containing them:EP,Patent 29,557,1995. |
【8】 Kameyama Y,Fukae K.Method for producing 3-vinyl-cephem compound:JP,Patent 2,001,294,590,2001. |
【9】 Takaya T,Shirai F,Nakamura H,et al.Novel crystalline 7-(2-(2-aminothiazol-4-yl)-2-hydroxyiminoacetamido)-3-vinyl-3-cephem-4-carboxylic acid(syn isomer):EP,Patent 304,019,1989. |
【10】 Lee GS,Chang YK,Chun JP,et al.Process for preparation of cefdinir:WO,Patent 9,724,358,1997. |
【11】 Sturm H,Wolf S,Ludescher J.Crystalline amine salt of cefdinir:WO,Patent 9,845,299,1998. |
中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
---|---|---|---|---|---|---|
(I) | 22747 | (6R,7R)-3-[(acetoxy)methyl]-7-amino-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid | C10H12N2O5S | 详情 | 详情 | |
(II) | 69618 | (6R,7R)-7-amino-3-(hydroxymethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid | C8H10N2O4S | 详情 | 详情 | |
(III) | 21351 | 2-Hydroxybenzaldehyde;Salicylic aldehyde;2-Formylphenol;salicylaldehyde | 90-02-8 | C7H6O2 | 详情 | 详情 |
(VIII) | 64882 | (6R,7R)-7-amino-8-oxo-3-vinyl-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid | 79349-82-9 | C9H10N2O3S | 详情 | 详情 |
(IX) | 69619 | (Z)-S-benzo[d]thiazol-2-yl 2-(2-aminothiazol-4-yl)-2-((trityloxy)imino)ethanethioate | C31H22N4O2S3 | 详情 | 详情 |
合成路线2
该中间体在本合成路线中的序号:(VII)
【1】 Huwiler A,Teund L.Production of 2-(2-aminothiazole-4-yl)-2- (syn)-methoxyimino acetic esters:EP,Patent 45,005,1982. |
【2】 胡艾希,徐娟娟,伍小云.氨噻肟酸乙酯的合成.中国医药工业杂 志.2206,37.229 |
【3】 程清蓉,刘志雄,李翔,等.去甲氨噻肟酸乙酯的合成研究.化学世界,2007,48:480 |
【4】 郑庚修,李贺,赵叶青.制备去甲氨噻肟酸乙酯的方法:CN,Patent 101,007,793,2007. |
【5】 Defossa E,Fischer G,Gerlach U,et al.Synthesis of HR 916 K.Am efficient route to the pure diastereomers of the 1-(pivaloyloxy)ethyl esters of cephalosporins.Liebigs Annalen,1996,(11):1743. |
【6】 Yamanaka H,Chiba T,Kawabata K,et al.Studies on β-lactam antibiotics.IX.Synthesis and biological activity of new orally active cephalosporin,cefixime(FK027).J Antibiotics,1985,38:1738. |
【7】 Takaya T,Takasugi H,Masugi T,et al.7-Acylamino-3-substituted cephalosporanic acid derivatives,processes for their preparation and pharmaceutical compositions containing them:EP,Patent 29,557,1995. |
【8】 Kameyama Y,Fukae K.Method for producing 3-vinyl-cephem compound:JP,Patent 2,001,294,590,2001. |
【9】 Takaya T,Shirai F,Nakamura H,et al.Novel crystalline 7-(2-(2-aminothiazol-4-yl)-2-hydroxyiminoacetamido)-3-vinyl-3-cephem-4-carboxylic acid(syn isomer):EP,Patent 304,019,1989. |
【10】 Lee GS,Chang YK,Chun JP,et al.Process for preparation of cefdinir:WO,Patent 9,724,358,1997. |
【11】 Sturm H,Wolf S,Ludescher J.Crystalline amine salt of cefdinir:WO,Patent 9,845,299,1998. |
中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
---|---|---|---|---|---|---|
(I) | 23541 | ethyl 4-chloro-3-oxobutanoate;Ethyl 4-chloro-3-oxobutanoate;Ethyl 4-chloroacetoacetate | 638-07-3 | C6H9ClO3 | 详情 | 详情 |
(II) | 39961 | ethyl 4-chloro-2-(hydroxyimino)-3-oxobutanoate;(Z)-ethyl 4-chloro-2-(hydroxyimino)-3-oxobutanoate | C6H8ClNO4 | 详情 | 详情 | |
(III) | 15889 | Ethyl 2-(2-aminothiazol-4-yl)-2-hydroxyiminoacetate;(Z)-ethyl 2-(2-aminothiazol-4-yl)-2-(hydroxyimino)acetate; ethyl 2-(2-amino-1,3-thiazol-4-yl)-2-(hydroxyimino)acetate | 60845-81-0 | C7H9N3O3S | 详情 | 详情 |
(IV) | 48461 | (Z)-ethyl 2-(2-aminothiazol-4-yl)-2-((trityloxy)imino)acetate;ethyl 2-(2-amino-1,3-thiazol-4-yl)-2-[(trityloxy)imino]acetate | C26H23N3O3S | 详情 | 详情 | |
(V) | 48462 | 2-(2-amino-1,3-thiazol-4-yl)-2-[(trityloxy)imino]acetic acid;(Z)-2-(2-aminothiazol-4-yl)-2-((trityloxy)imino)acetic acid | 128438-01-7 | C24H19N3O3S | 详情 | 详情 |
(VI) | 69620 | 1-(2,5-dimethoxyphenyl)propan-2-amine (Z)-2-(2-aminothiazol-4-yl)-2-((trityloxy)imino)acetate | C24H19N3O3S.C11H17NO2 | 详情 | 详情 | |
(VII) | 69619 | (Z)-S-benzo[d]thiazol-2-yl 2-(2-aminothiazol-4-yl)-2-((trityloxy)imino)ethanethioate | C31H22N4O2S3 | 详情 | 详情 | |
(VIII) | 10180 | Thiourea | 62-56-6 | CH4N2S | 详情 | 详情 |
合成路线3
该中间体在本合成路线中的序号:(III)
【1】 Cabri W,Alpegiani M,Pozzi G,et al.A process for the preparation of cephalosporins side chain:WO,Patent 2.003,040,116,2003. |
中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
---|---|---|---|---|---|---|
(I) | 10183 | (Z)-2-(2-aminothiazol-4-yl)-2-(hydroxyimino)acetic acid;2-(2-Amino-1,3-thiazol-4-yl)-2-(hydroxyimino)acetic acid | 66338-96-3 | C5H5N3O3S | 详情 | 详情 |
(II) | 69623 | triethylamine (Z)-2-(2-aminothiazol-4-yl)-2-((trityloxy)imino)acetate | C24H19N3O3S.C6H15N | 详情 | 详情 | |
(III) | 69619 | (Z)-S-benzo[d]thiazol-2-yl 2-(2-aminothiazol-4-yl)-2-((trityloxy)imino)ethanethioate | C31H22N4O2S3 | 详情 | 详情 |
Extended Information