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【结 构 式】 
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【分子编号】69594 【品名】(S)-1-(tert-butoxycarbonyl)pyrrolidine-2-carbothioic S-acid 【CA登记号】 |
【 分 子 式 】C10H17NO3S 【 分 子 量 】231.316 【元素组成】C 51.92% H 7.41% N 6.06% O 20.75% S 13.86% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(I)
| 【1】 Onedetti MA.Pyrrolo or pyrido[2,1-c][1,4] thiazines or thizapines:US,Patent 2,225,495,1980. |
| 【2】 Snatzke G,Decorte E,Kovac T,et al.Attempted diastereoselective preparation chiroptical properties of (2S)-1-(3-mercapto-2-methyl-1-oxo-propyl)-L-proline(captopril) and some congeners.Croat Chem Acta,1989,62:325. |
| 【3】 Evers MC.Captopril preparation by cyclisation and dehydration of N-2(S)-3-hydroxy 2-methyl-propionyl-S-thioproline and reaction of product with an aq or alcoholic base:NL,Patent 8,303,983,1985. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 69594 | (S)-1-(tert-butoxycarbonyl)pyrrolidine-2-carbothioic S-acid | C10H17NO3S | 详情 | 详情 | |
| (II) | 33550 | 2-methylacrylic acid | 79-41-4 | C4H6O2 | 详情 | 详情 |
| (III) | 69595 | 3-(((S)-1-(tert-butoxycarbonyl)pyrrolidine-2-carbonyl)thio)-2-methylpropanoic acid | C14H23NO5S | 详情 | 详情 | |
| (IV) | 69596 | 4-methylhexahydropyrrolo[2,1-c][1,4]thiazepine-1,5-dione | C9H13NO2S | 详情 | 详情 |
Extended Information