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【结 构 式】 
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【分子编号】69579 【品名】3-ethyl 5-methyl 4-(2-chlorophenyl)-2-((2-hydroxyethoxy)methyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate 【CA登记号】 |
【 分 子 式 】C20H24ClNO6 【 分 子 量 】409.866 【元素组成】C 58.61% H 5.90% Cl 8.65% N 3.42% O 23.42% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(VIII)
| 【1】 Artus Surroca JJ,Janet Bonet M,Rafecas Jane L.Intermediate compounds for obtaining main active anti-hypertensive agents together with corresponding procedures:ES,Patent 2,211,317,2004. |
| 【2】 Yiu SH,Knaus EE.Synthesis,calcium channel antagonist activity,and anticonvulsant activity of 3-ehtyl 5-methyl 1,4-dihydro-2-[(2-hydroxyethoxy)methyl]-6-methyl-4-(2,3-dichloro-phenyl)-3,5-pyridinedicarboxylate coupled to a 1-methyl-1,4-dihydropyridyl-3-carbonyl chemical delivery system. Arch Pharma,1999,332:363. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 11295 | Polyethylene glycol;1,2-Ethanediol;Monoethylene glycol; Ethylene glycol | 107-21-1 | C2H6O2 | 详情 | 详情 |
| (II) | 13684 | 3,4-Dihydro-2H-pyran;2,3-Dihydro-4H-pyran; 5,6-Dihydro-4H-pyran;Dihydropyran | 110-87-2 | C5H8O | 详情 | 详情 |
| (III) | 69576 | 2-((tetrahydro-2H-pyran-2-yl)oxy)ethanol | C7H14O3 | 详情 | 详情 | |
| (IV) | 23541 | ethyl 4-chloro-3-oxobutanoate；Ethyl 4-chloro-3-oxobutanoate；Ethyl 4-chloroacetoacetate | 638-07-3 | C6H9ClO3 | 详情 | 详情 |
| (V) | 69577 | ethyl 3-oxo-4-(2-((tetrahydro-2H-pyran-2-yl)oxy)ethoxy)butanoate | C13H22O6 | 详情 | 详情 | |
| (VI) | 69578 | ethyl 4-(2-hydroxyethoxy)-3-oxobutanoate | C8H14O5 | 详情 | 详情 | |
| (VII) | 44034 | methyl (Z)-2-acetyl-3-(2-chlorophenyl)-2-propenoate | C12H11ClO3 | 详情 | 详情 | |
| (VIII) | 69579 | 3-ethyl 5-methyl 4-(2-chlorophenyl)-2-((2-hydroxyethoxy)methyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate | C20H24ClNO6 | 详情 | 详情 | |
| (IX) | 69580 | 3-ethyl 5-methyl 4-(2-chlorophenyl)-6-methyl-2-((2-((methylsulfonyl)oxy)ethoxy)methyl)-1,4-dihydropyridine-3,5-dicarboxylate | C21H26ClNO8S | 详情 | 详情 | |
| (X) | 69570 | Benzenesulfonic acid;Phenylsulfonic acid;Benzenemonosulfonic acid;Benzensulfonic acid;Benzenesulphonic acid; | 98-11-3 | C6H6O3S | 详情 | 详情 |
Extended Information