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【结 构 式】 
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【分子编号】69539 【品名】N-acetyl-N-(2,4-dibromo-6-(bromomethyl)phenyl)acetamide 【CA登记号】 |
【 分 子 式 】C11H10Br3NO2 【 分 子 量 】427.918 【元素组成】C 30.88% H 2.35% Br 56.02% N 3.27% O 7.48% |
与该中间体有关的原料药合成路线共 2 条
合成路线1
该中间体在本合成路线中的序号：(VIII)
| 【1】 于书海，徐继健，杨健.盐酸氨溴索的合成.现代应用药学，1993,13:36. |
| 【2】 Lehmann B.Process for the preparation of trans-4-aminocyclohexanol by the hydrogenation of 4-acetamidophenol followed by hydrolysis and fractional crystallization:DE,Patent 17,745,529,1999. |
| 【3】 Keck J.Synthesis of metabolites of Bisolvon.Liebigs Ann Chem,1967,707:107. |
| 【4】 Schraven E,Koss FW,Keck J,et al.Excretion,isolation,and identification of the metabolites of Bisolvon. Eur J Pharmacol,1967,1:445. |
| 【5】 Kopitar Z,Jauch R,Hankwitz R,et al.Species differences in metabolism and excretion of bromhexine in mice,rates,rabbits,dogs,and man.Eur J Pharmacol,1973,21:6. |
| 【6】 Renovanz KD.Clinical-pharmacological studies on ambroxol(NA 872). Arzneimittel Forsch,1975,25:646. |
| 【7】 Pueschmann S,Engelhorn R.Pharmacological study on the bromhexine metabolite ambroxol.ArzneimitteForsch,1978,28:889. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 21611 | 4'-Hydroxyacetanilide;4-Acetamidophenol;N-Acetyl-4-aminophenol;Paracetamol;Acetaminophen;p-Hydroxyacetanilide; Paracetamol; N-(4-hydroxyphenyl)acetamide | 103-90-2 | C8H9NO2 | 详情 | 详情 |
| (II) | 69535 | N-(4-hydroxycyclohexyl)acetamide；4-Acetamidocyclohexanol | 23363-88-4 | C8H15NO2 | 详情 | 详情 |
| (III) | 19581 | trans-4-Aminocyclohexanol；trans-4-Amino-1-cyclohexanol;trans-4-Amino-1-cyclohexanol; | 27489-62-9 | C6H13NO | 详情 | 详情 |
| (IV) | 69536 | trans-4-Aminocyclohexanol hydrochloride;trans-4-Hydroxycyclohexylamine hydrochloride | 50910-54-8 | C6H13NO.HCl | 详情 | 详情 |
| (V) | 15511 | o-toluidine; 2-methylphenylamine;2-Methylaniline；2-Aminotoluene;1-Amino-2-methylbenzene;1-Methyl-2-aminobenzene; ortho-Toluidine | 95-53-4 | C7H9N | 详情 | 详情 |
| (VI) | 69537 | 2,4-Dibromo-6-methylbenzenamine;4,6-Dibromo-o-toluidine;2-Methyl-4,6-dibromoaniline;2-Amino-3,5-dibromotoluene;2,4-dibromo-6-methylaniline | 30273-41-7 | C7H7Br2N | 详情 | 详情 |
| (VII) | 69538 | N-acetyl-N-(2,4-dibromo-6-methylphenyl)acetamide | C11H11Br2NO2 | 详情 | 详情 | |
| (VIII) | 69539 | N-acetyl-N-(2,4-dibromo-6-(bromomethyl)phenyl)acetamide | C11H10Br3NO2 | 详情 | 详情 | |
| (IX) | 69540 | N-acetyl-N-(2,4-dibromo-6-(((trans-4-methylcyclohexyl)amino)methyl)phenyl)acetamide | C18H24Br2N2O2 | 详情 | 详情 |
合成路线2
该中间体在本合成路线中的序号：(I)
| 【1】 Ales Venero A,Mosquera Pestana R.Procedure for the preparation of ambroxol hydrochloride:ES,Patent 545,493,1986. |
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