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【结 构 式】 
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【分子编号】69527 【品名】methyl 10-bromo-5H-dibenzo[b,f]azepine-5-carboxylate 【CA登记号】 |
【 分 子 式 】C16H12BrNO2 【 分 子 量 】330.18082 【元素组成】C 58.2% H 3.66% Br 24.2% N 4.24% O 9.69% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(III)
| 【1】 Ansari SK,Bhat R,Kulkarni AK, et al.2003.Process for preparation of 10-methoxycarbamazepine by reaction of 10-methoxyiminostilbene with cyanic acid in the presence of weak acid. EP 1302464. |
| 【2】 Gutman D, Baidossi W. Method of preparation a 5H-dibenz[b,f]azepine-5-carboxamide. WO 2003106414. |
| 【3】 Muthukumaran M, Natarajan M, Thennati R. 2005.Process for reparation of 10-oxo-10,11-dihydro-10-oxo-5H-dibenz[b,f]azepine-5-carboxamide. WO 2005096709. |
| 【4】 Parenky C, Chaturvedi R. 2005. Novel process for reparation of 10-oxo-10,11-dihydro-10-oxo-5H-dibenz[b,f]azepine-5-carboxamide(oxcarbazepine) via intermedia, 10-methoxy-5H-dibenz[b,f]azepine-5-carbonyl chloride. WO 2005066133. |
| 【5】 Schmieder van de Vondervoort L, Bouttemy S, Heu F, et al. 2003. Low temperature, high conversion, liquid-phase benzylic oxidation with dioxygen by metal/NHPI-catalyzed co-oxidation with benzaldehude. European Journal of Organic Chemistry, (3):578-589. |
| 【6】 Sivakumar BV, Bhirud SB, Batchu C, et al.2005.Preparation of 5H-dibenz[b,f]azepinecarboxamides. US 2005203297. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 69525 | Dibenz[b,f]azepine-5-carbonyl chloride;Iminostilbene carbonyl chloride；5-Chlorocarbonyl iminostilbene;5H-dibenzo[b,f]azepine-5-carbonyl chloride | 33948-22-0 | C15H10ClNO | 详情 | 详情 |
| (II) | 69526 | 10,11-dibromo-10,11-dihydro-5H-dibenzo[b,f]azepine-5-carbonyl chloride | C15H10Br2ClNO | 详情 | 详情 | |
| (III) | 69527 | methyl 10-bromo-5H-dibenzo[b,f]azepine-5-carboxylate | C16H12BrNO2 | 详情 | 详情 | |
| (IV) | 24333 | 10-methoxy-5H-dibenzo[b,f]azepine;10-Methoxyiminostilbene | 4698-11-7 | C15H13NO | 详情 | 详情 |
Extended Information