【结 构 式】 |
【分子编号】69043 【品名】4-propyldihydrofuran-2(3H)-one 【CA登记号】 |
【 分 子 式 】C7H12O2 【 分 子 量 】128.17108 【元素组成】C 65.6% H 9.44% O 24.97% |
合成路线1
该中间体在本合成路线中的序号:(XXV)5-Hydroxy-4-propyl-2-furanone (V) is obtained by aldol condensation of glyoxylic acid (XXI) with valeraldehyde (XXII) in the presence of morpholine in heptane, followed by cyclization of the intermediate aldehyde acid under acidic conditions .
Preparation of iodoacyl chloride (VIII) starts with the conjugate addition of propylmagnesium bromide (XXIV) to 2-furanone (XXIII) in the presence of CuI and TMSCl in ethyl ether to produce 4-propylbutyrolactone (XXV), which undergoes lactone ring opening by means of iodotrimethylsilane in CH2Cl2, affording 3-(iodomethyl)hexanoic acid (XXVI), and finally, chlorination of acid (XXVI) with SOCl2 in benzene .
【1】 Surtees, J., Lurquin, F., Diouf, O. (UCB SA). Process for preparing 2-oxo-1-pyrrolidine derivatives. CA 2538938, EP 1667967, JP 2007515387, US 2007100150, US 7629474, WO 2005028435. |
【2】 Kenda, B.M., Matagne, A.C., Talaga, P.E. et al. Discovery of 4-substituted pyrrolidone butanamides as new agents with significant antiepileptic activity. J Med Chem 2004, 47(3): 530-49. |
中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
---|---|---|---|---|---|---|
(V) | 58391 | 5-hydroxy-4-propyl-2(5H)-furanone;5-hydroxy-4-propyl-2-furanone | 78920-10-2 | C7H10O3 | 详情 | 详情 |
(VIII) | 69031 | 3-(iodomethyl)hexanoyl chloride | C7H12ClIO | 详情 | 详情 | |
(XXI) | 15618 | 2-Oxoacetic acid; Glyoxylic Acid | 298-12-4 | C2H2O3 | 详情 | 详情 |
(XXII) | 13409 | n-Valeraldehyde; Pentanal | 110-62-3 | C5H10O | 详情 | 详情 |
(XXIII) | 19267 | 2(5H)-furanone;furan-2(5H)-one;2-Buten-1,4-olide | 497-23-4 | C4H4O2 | 详情 | 详情 |
(XXIV) | 10790 | Bromo(propyl)magnesium;bromopropylMagnesium;4-propylbutyrolactone;propylmagnesiumbromide;n-propylmagnesium bromide;Bromopropylmagnesium; | 927-77-5 | C3H7BrMg | 详情 | 详情 |
(XXV) | 69043 | 4-propyldihydrofuran-2(3H)-one | C7H12O2 | 详情 | 详情 | |
(XXVI) | 69044 | 3-(iodomethyl)hexanoic acid | C7H13IO2 | 详情 | 详情 |