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【结 构 式】 
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【分子编号】67077 【品名】2-(4-(benzyloxy)phenyl)-N,N-dimethylacetamide 【CA登记号】 |
【 分 子 式 】C17H20NO2 【 分 子 量 】270.351 【元素组成】C 75.53% H 7.46% N 5.18% O 11.84% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(III)
| 【1】 Gore VG, Kulkarni VS, Wakchaure VS, et al. 2008. Process for perparation of O-desmethyl venlafaxine(ODV) from phenylacetic acid derivatives, dimethylamino, and cyclohexanone. WO 2008093142. |
| 【2】 Niddam-Hildesheim V, Shenkar N, Shachan-Tov S. 2008. Process for the synthesis of O-desmethylvenlafaxine from 1-[2-amino-1-(4-methoxyphenyl) ethyl] cyclohexanol via O-demethylation and N-methylation reactions. WO 2008013995. |
| 【3】 Niddam-Hildesheim V, Shenkar N, Shachan-Tov S. 2008. Process for the synthesis of O-desmethylvenlafaxine from hydroxybenzyl cyanide via condensation reaction with cyclohexanone. WO 2008013993. |
| 【4】 Niddam-Hildesheim V, Shenkar N, Shachan-Tov S. 2008. Process for the synthesis of O-desmethylvenlafaxine from (4-hydroxyphenyl) acetic acid. WO 2008013990. |
| 【5】 Zupancic S, Skrabanja V. 2007. Process for praparation of O-desmethylvenlafaxine. WO 2007147564. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (II) | 67076 | 2-(4-(benzyloxy)phenyl)acetyl chloride | C15H14ClO2 | 详情 | 详情 | |
| (I) | 67075 | 2-(4-(benzyloxy)phenyl)acetic acid | C15H14O3 | 详情 | 详情 | |
| (III) | 67077 | 2-(4-(benzyloxy)phenyl)-N,N-dimethylacetamide | C17H20NO2 | 详情 | 详情 | |
| (IV) | 11059 | Cyclohexanone | 108-94-1 | C6H10O | 详情 | 详情 |
| (V) | 67078 | 2-(4-(benzyloxy)phenyl)-2-(1-hydroxycyclohexyl)-N,N-dimethylacetamide | C23H30NO3 | 详情 | 详情 |
Extended Information