Desvenlafaxine Succinate, O-Desmethylvenlafaxine，DVS-233，WY-45233 (as free base), -Drug Synthesis Database

【结构式】

【药物名称】Desvenlafaxine Succinate, O-Desmethylvenlafaxine，DVS-233，WY-45233 (as free base)

【化学名称】4-[2-(Dimethylamino)-1-(hydroxycyclohexyl)ethyl]phenol succinate hydrate

【CA登记号】386750-22-7（succinate monohydrate）;93413-62-8（free base）

【分子式】C₂₀H₃₃NO₇, 93413-62-8 (as free base, anhydrous)

【分子量】399.4786

【开发单位】Wyeth Pharmaceuticals (US).

【药理作用】Antidepressant, Treatment of postmenopausal syndrome, 5-HT and norepinephrine reuptake inhibitor

【1】 Gore VG, Kulkarni VS, Patil M. 2009. Process for perparation of O-desmethylvenlafaxine via treatment of venlafaxine with a thiol reagent. WO 2009053731.
【2】 Modi IA, Muktawat S, Singh UP, et al. 2009. Preparation of O-desmethylvenlafaxine by demethylation of venlafaxine. WO 2009034434.
【3】 Niddam-Hildesheim V, Nidam T, Dolitzky. 2009. Process for the synthesis of O-desmethylvenlafaxine including tridesmethylvenlafaxime as an intermediate, US 2009069601; US 2008221356.
【4】 Tyagi OD, Lahari S, Koilkonda P, et al. 2009.Process for producing 1-[2-(dimethylamino)-1-(4-hydroxyphenyl) ethyl] cyclohexanol. WO 20090840039.
【5】 Srinivasan CV, Aggarwal AK, Sarin GS, et al. 2009. Improved process for the preparation of O-desmethyl-venlafaxine. WO 2009084038.
【6】 Xu JK, Xu MD, Cai YX, et al.2009.Novel method for preparation of O-desvenlafaxine. 发明专利申请公开说明书. CN 101117320.

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	32753	2-(4-hydroxyphenyl)acetonitrile; 4-Hydroxybenzyl cyanide	14191-95-8	C₈H₇NO	详情	详情
(II)	67072	2-(4-(benzyloxy)phenyl)acetonitrile 英文名称为：		C₁₅H₁₃NO	详情	详情
(III)	11059	Cyclohexanone	108-94-1	C₆H₁₀O	详情	详情
(IV)	67073	2-(4-(benzyloxy)phenyl)-2-(1-hydroxycyclohexyl)acetonitrile		C₂₁H₂₃NO₂	详情	详情
(V)	67074	1-(2-amino-1-(4-(benzyloxy)phenyl)ethyl)cyclohexanol		C₂₁H₂₇NO₂	详情	详情

【1】 Gore VG, Kulkarni VS, Wakchaure VS, et al. 2008. Process for perparation of O-desmethyl venlafaxine(ODV) from phenylacetic acid derivatives, dimethylamino, and cyclohexanone. WO 2008093142.
【2】 Niddam-Hildesheim V, Shenkar N, Shachan-Tov S. 2008. Process for the synthesis of O-desmethylvenlafaxine from 1-[2-amino-1-(4-methoxyphenyl) ethyl] cyclohexanol via O-demethylation and N-methylation reactions. WO 2008013995.
【3】 Niddam-Hildesheim V, Shenkar N, Shachan-Tov S. 2008. Process for the synthesis of O-desmethylvenlafaxine from hydroxybenzyl cyanide via condensation reaction with cyclohexanone. WO 2008013993.
【4】 Niddam-Hildesheim V, Shenkar N, Shachan-Tov S. 2008. Process for the synthesis of O-desmethylvenlafaxine from (4-hydroxyphenyl) acetic acid. WO 2008013990.
【5】 Zupancic S, Skrabanja V. 2007. Process for praparation of O-desmethylvenlafaxine. WO 2007147564.

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(II)	67076	2-(4-(benzyloxy)phenyl)acetyl chloride		C₁₅H₁₄ClO₂	详情	详情
(I)	67075	2-(4-(benzyloxy)phenyl)acetic acid		C₁₅H₁₄O₃	详情	详情
(III)	67077	2-(4-(benzyloxy)phenyl)-N,N-dimethylacetamide		C₁₇H₂₀NO₂	详情	详情
(IV)	11059	Cyclohexanone	108-94-1	C₆H₁₀O	详情	详情
(V)	67078	2-(4-(benzyloxy)phenyl)-2-(1-hydroxycyclohexyl)-N,N-dimethylacetamide		C₂₃H₃₀NO₃	详情	详情

Extended Information