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【结 构 式】 
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【分子编号】67073 【品名】2-(4-(benzyloxy)phenyl)-2-(1-hydroxycyclohexyl)acetonitrile 【CA登记号】 |
【 分 子 式 】C21H23NO2 【 分 子 量 】321.41916 【元素组成】C 78.47% H 7.21% N 4.36% O 9.96% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(IV)
| 【1】 Gore VG, Kulkarni VS, Patil M. 2009. Process for perparation of O-desmethylvenlafaxine via treatment of venlafaxine with a thiol reagent. WO 2009053731. |
| 【2】 Modi IA, Muktawat S, Singh UP, et al. 2009. Preparation of O-desmethylvenlafaxine by demethylation of venlafaxine. WO 2009034434. |
| 【3】 Niddam-Hildesheim V, Nidam T, Dolitzky. 2009. Process for the synthesis of O-desmethylvenlafaxine including tridesmethylvenlafaxime as an intermediate, US 2009069601; US 2008221356. |
| 【4】 Tyagi OD, Lahari S, Koilkonda P, et al. 2009.Process for producing 1-[2-(dimethylamino)-1-(4-hydroxyphenyl) ethyl] cyclohexanol. WO 20090840039. |
| 【5】 Srinivasan CV, Aggarwal AK, Sarin GS, et al. 2009. Improved process for the preparation of O-desmethyl-venlafaxine. WO 2009084038. |
| 【6】 Xu JK, Xu MD, Cai YX, et al.2009.Novel method for preparation of O-desvenlafaxine. 发明专利申请公开说明书. CN 101117320. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 32753 | 2-(4-hydroxyphenyl)acetonitrile; 4-Hydroxybenzyl cyanide | 14191-95-8 | C8H7NO | 详情 | 详情 |
| (II) | 67072 | 2-(4-(benzyloxy)phenyl)acetonitrile 英文名称为： | C15H13NO | 详情 | 详情 | |
| (III) | 11059 | Cyclohexanone | 108-94-1 | C6H10O | 详情 | 详情 |
| (IV) | 67073 | 2-(4-(benzyloxy)phenyl)-2-(1-hydroxycyclohexyl)acetonitrile | C21H23NO2 | 详情 | 详情 | |
| (V) | 67074 | 1-(2-amino-1-(4-(benzyloxy)phenyl)ethyl)cyclohexanol | C21H27NO2 | 详情 | 详情 |
Extended Information