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【结 构 式】 
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【分子编号】67059 【品名】 【CA登记号】 |
【 分 子 式 】C21H25ClN2O3 【 分 子 量 】388.89388 【元素组成】C 64.86% H 6.48% Cl 9.12% N 7.2% O 12.34% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(IX)
| 【1】 Ha TH, Parks CH, Kim WJ, et al. 2008. Process for preparing bepotastine and intermediates used therein. WO 2008153289 (Hanmi Pharm Co Ltd, S Korea). Krueger W, Krueger G. 1983. 4-[1-methyl-5-bis[(2-chloroethyl) amino] -2-benzimidazolyl] butyric acid. Ger, (East)DD 159877. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (VII) | 67057 | (2R,5R)-2-isopropyl-5-methylcyclohexyl 4-(4-((S)-(4-chlorophenyl)(pyridin-2-yl)methoxy)piperidin-1-yl)butanoate (R)-2-(((benzyloxy)carbonyl)amino)succinate | C31H43ClN2O3.C12H13NO6 | 详情 | 详情 | |
| (I) | 11265 | 4-Chlorobutanoyl chloride; 4-Chlorobutyric acid chloride | 4635-59-0 | C4H6Cl2O | 详情 | 详情 |
| (II) | 67053 | (1R,5R)-2-isopropyl-5-methylcyclohexanol | C10H20O | 详情 | 详情 | |
| (III) | 67054 | (1S,5S)-2-isopropyl-5-methylcyclohexyl 4-chlorobutanoate | C14H25ClO2 | 详情 | 详情 | |
| (IV) | 16053 | 2-[(4-chlorophenyl)(4-piperidinyloxy)methyl]pyridine; (4-chlorophenyl)(2-pyridinyl)methyl 4-piperidinyl ether | C17H19ClN2O | 详情 | 详情 | |
| (V) | 67055 | (1S,2R)-2-isopropyl-5-methylcyclohexyl 4-(4-((4-chlorophenyl)(pyridin-2-yl)methoxy)piperidin-1-yl)butanoate | C31H43ClN2O3 | 详情 | 详情 | |
| (VI) | 67056 | (S)-2-(((benzyloxy)carbonyl)amino)succinic acid | C12H13NO6 | 详情 | 详情 | |
| (VIII) | 67058 | (2R,5R)-2-isopropyl-5- methylcyclohexyl 4-(4-((S)-(4-chlorophenyl)(pyridin-2 -yl)methoxy)piperidin-1-yl)butanoate | C31H43ClN2O3 | 详情 | 详情 | |
| (IX) | 67059 | C21H25ClN2O3 | 详情 | 详情 |
Extended Information