(2R,5R)-2-isopropyl-5- methylcyclohexyl 4-(4-((S)-(4-chlorophenyl)(pyridin-2 -yl)methoxy)piperidin-1-yl)butanoate -Drug Synthesis Database

【结构式】

【分子编号】67058

【品名】(2R,5R)-2-isopropyl-5- methylcyclohexyl 4-(4-((S)-(4-chlorophenyl)(pyridin-2 -yl)methoxy)piperidin-1-yl)butanoate

【CA登记号】　

【分子式】C₃₁H₄₃ClN₂O₃

【分子量】527.147

【元素组成】C 70.63% H 8.22% Cl 6.73% N 5.31% O 9.10%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(VIII)

【1】 Ha TH, Parks CH, Kim WJ, et al. 2008. Process for preparing bepotastine and intermediates used therein. WO 2008153289 (Hanmi Pharm Co Ltd, S Korea). Krueger W, Krueger G. 1983. 4-[1-methyl-5-bis[(2-chloroethyl) amino] -2-benzimidazolyl] butyric acid. Ger, (East)DD 159877.

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(VII)	67057	(2R,5R)-2-isopropyl-5-methylcyclohexyl 4-(4-((S)-(4-chlorophenyl)(pyridin-2-yl)methoxy)piperidin-1-yl)butanoate (R)-2-(((benzyloxy)carbonyl)amino)succinate		C₃₁H₄₃ClN₂O₃.C₁₂H₁₃NO₆	详情	详情
(I)	11265	4-Chlorobutanoyl chloride; 4-Chlorobutyric acid chloride	4635-59-0	C₄H₆Cl₂O	详情	详情
(II)	67053	(1R,5R)-2-isopropyl-5-methylcyclohexanol		C₁₀H₂₀O	详情	详情
(III)	67054	(1S,5S)-2-isopropyl-5-methylcyclohexyl 4-chlorobutanoate		C₁₄H₂₅ClO₂	详情	详情
(IV)	16053	2-[(4-chlorophenyl)(4-piperidinyloxy)methyl]pyridine; (4-chlorophenyl)(2-pyridinyl)methyl 4-piperidinyl ether		C₁₇H₁₉ClN₂O	详情	详情
(V)	67055	(1S,2R)-2-isopropyl-5-methylcyclohexyl 4-(4-((4-chlorophenyl)(pyridin-2-yl)methoxy)piperidin-1-yl)butanoate		C₃₁H₄₃ClN₂O₃	详情	详情
(VI)	67056	(S)-2-(((benzyloxy)carbonyl)amino)succinic acid		C₁₂H₁₃NO₆	详情	详情
(VIII)	67058	(2R,5R)-2-isopropyl-5- methylcyclohexyl 4-(4-((S)-(4-chlorophenyl)(pyridin-2 -yl)methoxy)piperidin-1-yl)butanoate		C₃₁H₄₃ClN₂O₃	详情	详情
(IX)	67059			C₂₁H₂₅ClN₂O₃	详情	详情

Extended Information