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【结 构 式】 
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【分子编号】66998 【品名】 【CA登记号】 |
【 分 子 式 】C32H40N2O6S 【 分 子 量 】580.74548 【元素组成】C 66.18% H 6.94% N 4.82% O 16.53% S 5.52% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(VIII)
| 【1】 Lindsay KB. Skrydstrup T. 2006. Formal total synthesisi of the potent renin inhibitory aliskiren: Application of a Sml-promoted acyl-like radical coupling. J Org Chem, 71(13): 4766～4777 |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (XI) | 67001 | benzyl (1-(4-(2-hydroxypropan-2-yl)-5-oxotetrahydrofuran-2-yl)-3-(4-methoxy-3-(3-methoxypropoxy)benzyl)-4-methylpentyl)carbamate | C33H47NO8 | 详情 | 详情 | |
| (I) | 28120 | 3-[5-[(2R)-2-(bromomethyl)-3-methylbutyl]-2-methoxyphenoxy]propyl methyl ether | 172900-69-5 | C17H27BrO3 | 详情 | 详情 |
| (II) | 10296 | (R)-2,5-Dihydro-3,6-dimethoxy-2-isopropylpyrazine; (3R)-3-Isopropyl-5-methoxy-3,6-dihydro-2-pyrazinyl methyl ether; (2R)-2-Isopropyl-3,6-dimethoxy-2,5-dihydropyrazine | 109838-85-9 | C9H16N2O2 | 详情 | 详情 |
| (III) | 28121 | (2R,5S)-2-isopropyl-3,6-dimethoxy-5-[(2S)-2-[4-methoxy-3-(3-methoxypropoxy)benzyl]-3-methylbutyl]-2,5-dihydropyrazine | C26H42N2O5 | 详情 | 详情 | |
| (IV) | 66995 | (2R,4R)-methyl 2-amino-4-(4-methoxy-3-(3-methoxypropoxy)benzyl)-5-methylhexanoate | C20H33NO5 | 详情 | 详情 | |
| (V) | 66996 | methyl 2-(((benzyloxy)carbonyl)amino)-4-(4-methoxy-3-(3-methoxypropoxy)benzyl)-5-methylhexanoate | C28H39NO7 | 详情 | 详情 | |
| (VI) | 66997 | 2-(((benzyloxy)carbonyl)amino)-4-(4-methoxy-3-(3-methoxypropoxy)benzyl)-5-methylhexanoic acid | C27H37NO7 | 详情 | 详情 | |
| (VII) | 27936 | 4-Mercaptopyridine; 4-pyridinethiol | 4556-23-4 | C5H5NS | 详情 | 详情 |
| (VIII) | 66998 | C32H40N2O6S | 详情 | 详情 | ||
| (IX) | 66999 | methyl 5-(((benzyloxy)carbonyl)amino)-7-(4-methoxy-3-(3-methoxypropoxy)benzyl)-8-methyl-4-oxononanoate | C31H43NO8 | 详情 | 详情 | |
| (X) | 67000 | benzyl (3-(4-methoxy-3-(3-methoxypropoxy)benzyl)-4-methyl-1-(5-oxotetrahydrofuran-2-yl)pentyl)carbamate | C30H41NO7 | 详情 | 详情 | |
| (XII) | 67002 | benzyl (3-(4-methoxy-3-(3-methoxypropoxy)benzyl)-4-methyl-1-(5-oxo-4-(prop-1-en-2-yl)tetrahydrofuran-2-yl)pentyl)carbamate | C33H45NO7 | 详情 | 详情 | |
| (XIII) | 67003 | 5-(1-amino-3-(4-methoxy-3-(3-methoxypropoxy)benzyl)-4-methylpentyl)-3-isopropyldihydrofuran-2(3H)-one | C25H41NO5 | 详情 | 详情 | |
| (XIV) | 67004 | tert-butyl (1-(4-isopropyl-5-oxotetrahydrofuran-2-yl)-3-(4-methoxy-3-(3-methoxypropoxy)benzyl)-4-methylpentyl)carbamate | C30H49NO7 | 详情 | 详情 | |
| (XV) | 28129 | 3-amino-2,2-dimethylpropanamide | 324763-51-1 | C5H12N2O | 详情 | 详情 |
| (XVI) | 67005 | tert-butyl (8-((3-amino-2,2-dimethyl-3-oxopropyl)carbamoyl)-6-hydroxy-3-(4-methoxy-3-(3-methoxypropoxy)benzyl)-2,9-dimethyldecan-5-yl)carbamate | C35H61N3O8 | 详情 | 详情 |
Extended Information