methyl 2-(((benzyloxy)carbonyl)amino)-4-(4-methoxy-3-(3-methoxypropoxy)benzyl)-5-methylhexanoate -Drug Synthesis Database

【结构式】

【分子编号】66996

【品名】methyl 2-(((benzyloxy)carbonyl)amino)-4-(4-methoxy-3-(3-methoxypropoxy)benzyl)-5-methylhexanoate

【CA登记号】　

【分子式】C₂₈H₃₉NO₇

【分子量】501.6202

【元素组成】C 67.04% H 7.84% N 2.79% O 22.33%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(V)

参考文献中间体

合成目标

【1】 Lindsay KB. Skrydstrup T. 2006. Formal total synthesisi of the potent renin inhibitory aliskiren: Application of a Sml-promoted acyl-like radical coupling. J Org Chem, 71(13): 4766～4777

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(XI)	67001	benzyl (1-(4-(2-hydroxypropan-2-yl)-5-oxotetrahydrofuran-2-yl)-3-(4-methoxy-3-(3-methoxypropoxy)benzyl)-4-methylpentyl)carbamate		C₃₃H₄₇NO₈	详情	详情
(I)	28120	3-[5-[(2R)-2-(bromomethyl)-3-methylbutyl]-2-methoxyphenoxy]propyl methyl ether	172900-69-5	C₁₇H₂₇BrO₃	详情	详情
(II)	10296	(R)-2,5-Dihydro-3,6-dimethoxy-2-isopropylpyrazine; (3R)-3-Isopropyl-5-methoxy-3,6-dihydro-2-pyrazinyl methyl ether; (2R)-2-Isopropyl-3,6-dimethoxy-2,5-dihydropyrazine	109838-85-9	C₉H₁₆N₂O₂	详情	详情
(III)	28121	(2R,5S)-2-isopropyl-3,6-dimethoxy-5-[(2S)-2-[4-methoxy-3-(3-methoxypropoxy)benzyl]-3-methylbutyl]-2,5-dihydropyrazine		C₂₆H₄₂N₂O₅	详情	详情
(IV)	66995	(2R,4R)-methyl 2-amino-4-(4-methoxy-3-(3-methoxypropoxy)benzyl)-5-methylhexanoate		C₂₀H₃₃NO₅	详情	详情
(V)	66996	methyl 2-(((benzyloxy)carbonyl)amino)-4-(4-methoxy-3-(3-methoxypropoxy)benzyl)-5-methylhexanoate		C₂₈H₃₉NO₇	详情	详情
(VI)	66997	2-(((benzyloxy)carbonyl)amino)-4-(4-methoxy-3-(3-methoxypropoxy)benzyl)-5-methylhexanoic acid		C₂₇H₃₇NO₇	详情	详情
(VII)	27936	4-Mercaptopyridine; 4-pyridinethiol	4556-23-4	C₅H₅NS	详情	详情
(VIII)	66998			C₃₂H₄₀N₂O₆S	详情	详情
(IX)	66999	methyl 5-(((benzyloxy)carbonyl)amino)-7-(4-methoxy-3-(3-methoxypropoxy)benzyl)-8-methyl-4-oxononanoate		C₃₁H₄₃NO₈	详情	详情
(X)	67000	benzyl (3-(4-methoxy-3-(3-methoxypropoxy)benzyl)-4-methyl-1-(5-oxotetrahydrofuran-2-yl)pentyl)carbamate		C₃₀H₄₁NO₇	详情	详情
(XII)	67002	benzyl (3-(4-methoxy-3-(3-methoxypropoxy)benzyl)-4-methyl-1-(5-oxo-4-(prop-1-en-2-yl)tetrahydrofuran-2-yl)pentyl)carbamate		C₃₃H₄₅NO₇	详情	详情
(XIII)	67003	5-(1-amino-3-(4-methoxy-3-(3-methoxypropoxy)benzyl)-4-methylpentyl)-3-isopropyldihydrofuran-2(3H)-one		C₂₅H₄₁NO₅	详情	详情
(XIV)	67004	tert-butyl (1-(4-isopropyl-5-oxotetrahydrofuran-2-yl)-3-(4-methoxy-3-(3-methoxypropoxy)benzyl)-4-methylpentyl)carbamate		C₃₀H₄₉NO₇	详情	详情
(XV)	28129	3-amino-2,2-dimethylpropanamide	324763-51-1	C₅H₁₂N₂O	详情	详情
(XVI)	67005	tert-butyl (8-((3-amino-2,2-dimethyl-3-oxopropyl)carbamoyl)-6-hydroxy-3-(4-methoxy-3-(3-methoxypropoxy)benzyl)-2,9-dimethyldecan-5-yl)carbamate		C₃₅H₆₁N₃O₈	详情	详情

Extended Information