【结 构 式】 |
【分子编号】66820 【品名】5-amino-1H-imidazole-4-carboxamide hydrochloride 【CA登记号】21299-72-9 |
【 分 子 式 】C4H6N4O.HCl 【 分 子 量 】162.579 【元素组成】C 29.55% H 4.34% Cl 21.81% N 34.46% O 9.84% |
与该中间体有关的原料药合成路线共 4 条
合成路线1
该中间体在本合成路线中的序号:(IV)
【1】 Ku SC. 2002. A process tor the prepn. of temoiolomide and its analogs via the oxiadative cyclization of 5-amino-4-aminocarbonylirmdazolylbyrkuides. W0 2002057268 |
中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
---|---|---|---|---|---|---|
(I) | 66818 | 2-amino-2-cyanoacetamide;Aminocyanacetamide | 6719-21-7 | C3H5N3O | 详情 | 详情 |
(II) | 66815 | (E)-N,N'-bis(methylcarbamoyl)formimidamide | C5H10N4O2 | 详情 | 详情 | |
(III) | 66819 | 5-amino-N1-methyl-1H-imidazole-1,4-dicarboxamide | C6H9N5O2 | 详情 | 详情 | |
(IV) | 66820 | 5-amino-1H-imidazole-4-carboxamide hydrochloride | 21299-72-9 | C4H6N4O.HCl | 详情 | 详情 |
(V) | 66811 | 2-amino-N-(tert-butyl)-2-cyanoacetamide | C7H13N3O | 详情 | 详情 | |
(VI) | 66816 | 5-amino-N4-(tert-butyl)-N1-methyl-1H-imidazole-1,4-dicarboxamide | C10H17N5O2 | 详情 | 详情 | |
(VII) | 66821 | 4-nitrophenyl 5-amino-4-carbamoyl-1H-imidazole-1-carboxylate | C11H9N5O5 | 详情 | 详情 | |
(VIII) | 66822 | 5-amino-1-(1-methylhydrazinecarbonyl)-1H-imidazole-4-carboxamide | C6H10N6O2 | 详情 | 详情 |
合成路线2
该中间体在本合成路线中的序号:(I)
【1】 Stevens MF, Hickman JA, StoneR,et al.1984. Antitumour imidazotetnzines. 1. Synthesis an chemistry of 8-carbamoyl-3-(2-chloroethyl) imidazo[5,1-d] -1,2,3,5-tetrazirr4(3H) -one.a novel broad-spectrum antitumor agent. J Med Chem, 27(2):196~201 |
合成路线3
该中间体在本合成路线中的序号:(I)
【1】 Wang YF, Stevens MF. 1996. Synthetic studies of 8-arbamoylimidazo-[5,l-D] -1,2,3,5-tetnzin-4(3H)-one: a key derivative of antitumor drug ternozolomide. Bioorg Med Chem lett, 6(2):185~188 |
合成路线4
该中间体在本合成路线中的序号:(I)
【1】 Wang YF, Stevens MF, Thomson W. 1994. Altemative syntheses of the antitumor drug temozolomide avoiding the use of methyl isocyanate. Journal of the Chemical Society, Chenucal Communications, (14): 1687~1688. |
中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
---|---|---|---|---|---|---|
(I) | 66820 | 5-amino-1H-imidazole-4-carboxamide hydrochloride | 21299-72-9 | C4H6N4O.HCl | 详情 | 详情 |
(II) | 66824 | ethyl 2-(5-amino-4-carbamoyl-1H-imidazole-1-carboxamido)acetate hydrochloride | C9H13N5O4.HCl | 详情 | 详情 | |
(III) | 66825 | ethyl 2-(8-carbamoyl-4-methyleneimidazo[5,1-d][1,2,3,5]tetrazin-3(4H)-yl)acetate | C10H12N6O3 | 详情 | 详情 | |
(IV) | 66826 | 2-(8-carbamoyl-4-methyleneimidazo[5,1-d][1,2,3,5]tetrazin-3(4H)-yl)acetic acid | C8H8N6O3 | 详情 | 详情 | |
(V) | 66827 | 2-thioxopyridin-1(2H)-yl 2-(8-carbamoyl-4-methyleneimidazo[5,1-d][1,2,3,5]tetrazin-3(4H)-yl)acetate | C13H11N7O3S | 详情 | 详情 |
Extended Information