【结 构 式】 |
【分子编号】56930 【品名】4-diazo-4H-imidazole-5-carboxamide 【CA登记号】 |
【 分 子 式 】C4H3N5O 【 分 子 量 】137.10092 【元素组成】C 35.04% H 2.21% N 51.08% O 11.67% |
与该中间体有关的原料药合成路线共 4 条
合成路线1
该中间体在本合成路线中的序号:(I)This compound has been obtained by two related ways: 1. The reaction of 5-diazoimidazole (I) with methylamine gives the triazene (II), which is then cyclized with 11C-phosgene (III) to yield the target 11C-carbonyl labeled compound. 2. The cyclization of 5-diazoimidazole-4-carboxamide (I) with 11C-carbonyl labeled methyl isocyanate (IV) gives the target 11C carbonyl labeled compound.
【1】 Brock, C.S.; Brady, F.; Stevens, M.F.G.; Brown, G.D.; Price, P.M.; Luthra, S.K.; Antitumor imidazotetrazines. 40.(1) Radiosyntheses of [4-11C-carbonyl]- and 3-N-11C-methyl]-8-carbamoyl-3- methylimidazo[5,1-d]-1,2,3,5-tetrazin-4(3H)-one (temozolomide) for positron emission tomography (PET) studies. J Med Chem 2002, 45, 25, 5448. |
中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
---|---|---|---|---|---|---|
(I) | 56930 | 4-diazo-4H-imidazole-5-carboxamide | C4H3N5O | 详情 | 详情 | |
(II) | 56931 | 4-[(E)-3-methyl-2-triazenyl]-4H-imidazole-5-carboxamide | C5H8N6O | 详情 | 详情 | |
(III) | 56932 | Carbonyl chloride | CCl2O | 详情 | 详情 | |
(III) | 56933 | carbonic dichloride | CCl2O | 详情 | 详情 | |
(IV) | 11019 | (Methylimino)(oxo)methane; methyl isocyanate | C2H3NO | 详情 | 详情 | |
(IV) | 56934 | (methylimino)(oxo)methane; methyl isocyanate | C2H3NO | 详情 | 详情 |
合成路线2
该中间体在本合成路线中的序号:(I)The cyclization of 5-diazoimidazole-4-carboxamide (I) with 11C-methyl isocyanate (II) gives the target 11C methyl labelled compound.
【1】 Brock, C.S.; Brady, F.; Stevens, M.F.G.; Brown, G.D.; Price, P.M.; Luthra, S.K.; Antitumor imidazotetrazines. 40.(1) Radiosyntheses of [4-11C-carbonyl]- and 3-N-11C-methyl]-8-carbamoyl-3- methylimidazo[5,1-d]-1,2,3,5-tetrazin-4(3H)-one (temozolomide) for positron emission tomography (PET) studies. J Med Chem 2002, 45, 25, 5448. |
合成路线3
该中间体在本合成路线中的序号:(II)
【1】 Stevens MF, Hickman JA, StoneR,et al.1984. Antitumour imidazotetnzines. 1. Synthesis an chemistry of 8-carbamoyl-3-(2-chloroethyl) imidazo[5,1-d] -1,2,3,5-tetrazirr4(3H) -one.a novel broad-spectrum antitumor agent. J Med Chem, 27(2):196~201 |
合成路线4
该中间体在本合成路线中的序号:(II)
【1】 Wang YF, Stevens MF. 1996. Synthetic studies of 8-arbamoylimidazo-[5,l-D] -1,2,3,5-tetnzin-4(3H)-one: a key derivative of antitumor drug ternozolomide. Bioorg Med Chem lett, 6(2):185~188 |
Extended Information