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【结 构 式】 
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【分子编号】56934 【品名】(methylimino)(oxo)methane; methyl isocyanate 【CA登记号】 |
【 分 子 式 】C2H3NO 【 分 子 量 】57.05196 【元素组成】C 42.11% H 5.3% N 24.55% O 28.04% |
与该中间体有关的原料药合成路线共 2 条
合成路线1
该中间体在本合成路线中的序号：(IV)This compound has been obtained by two related ways: 1. The reaction of 5-diazoimidazole (I) with methylamine gives the triazene (II), which is then cyclized with 11C-phosgene (III) to yield the target 11C-carbonyl labeled compound. 2. The cyclization of 5-diazoimidazole-4-carboxamide (I) with 11C-carbonyl labeled methyl isocyanate (IV) gives the target 11C carbonyl labeled compound.
| 【1】 Brock, C.S.; Brady, F.; Stevens, M.F.G.; Brown, G.D.; Price, P.M.; Luthra, S.K.; Antitumor imidazotetrazines. 40.(1) Radiosyntheses of [4-11C-carbonyl]- and 3-N-11C-methyl]-8-carbamoyl-3- methylimidazo[5,1-d]-1,2,3,5-tetrazin-4(3H)-one (temozolomide) for positron emission tomography (PET) studies. J Med Chem 2002, 45, 25, 5448. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 56930 | 4-diazo-4H-imidazole-5-carboxamide | C4H3N5O | 详情 | 详情 | |
| (II) | 56931 | 4-[(E)-3-methyl-2-triazenyl]-4H-imidazole-5-carboxamide | C5H8N6O | 详情 | 详情 | |
| (III) | 56932 | Carbonyl chloride | CCl2O | 详情 | 详情 | |
| (III) | 56933 | carbonic dichloride | CCl2O | 详情 | 详情 | |
| (IV) | 11019 | (Methylimino)(oxo)methane; methyl isocyanate | C2H3NO | 详情 | 详情 | |
| (IV) | 56934 | (methylimino)(oxo)methane; methyl isocyanate | C2H3NO | 详情 | 详情 |
合成路线2
该中间体在本合成路线中的序号：(II)The cyclization of 5-diazoimidazole-4-carboxamide (I) with 11C-methyl isocyanate (II) gives the target 11C methyl labelled compound.
| 【1】 Brock, C.S.; Brady, F.; Stevens, M.F.G.; Brown, G.D.; Price, P.M.; Luthra, S.K.; Antitumor imidazotetrazines. 40.(1) Radiosyntheses of [4-11C-carbonyl]- and 3-N-11C-methyl]-8-carbamoyl-3- methylimidazo[5,1-d]-1,2,3,5-tetrazin-4(3H)-one (temozolomide) for positron emission tomography (PET) studies. J Med Chem 2002, 45, 25, 5448. |
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