ethyl 2-(8-carbamoyl-4-methyleneimidazo[5,1-d][1,2,3,5]tetrazin-3(4H)-yl)acetate -Drug Synthesis Database

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【结构式】

【分子编号】66825

【品名】ethyl 2-(8-carbamoyl-4-methyleneimidazo[5,1-d][1,2,3,5]tetrazin-3(4H)-yl)acetate

【CA登记号】　

【分子式】C₁₀H₁₂N₆O₃

【分子量】264.244

【元素组成】C 45.45% H 4.58% N 31.80% O 18.16%

与该中间体有关的原料药合成路线共 1 条

合成路线1

合成路线1

该中间体在本合成路线中的序号：(III)

　

参考文献中间体

【1】 Wang YF, Stevens MF, Thomson W. 1994. Altemative syntheses of the antitumor drug temozolomide avoiding the use of methyl isocyanate. Journal of the Chemical Society, Chenucal Communications, (14): 1687～1688.

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	66820	5-amino-1H-imidazole-4-carboxamide hydrochloride	21299-72-9	C₄H₆N₄O.HCl	详情	详情
(II)	66824	ethyl 2-(5-amino-4-carbamoyl-1H-imidazole-1-carboxamido)acetate hydrochloride		C₉H₁₃N₅O₄.HCl	详情	详情
(III)	66825	ethyl 2-(8-carbamoyl-4-methyleneimidazo[5,1-d][1,2,3,5]tetrazin-3(4H)-yl)acetate		C₁₀H₁₂N₆O₃	详情	详情
(IV)	66826	2-(8-carbamoyl-4-methyleneimidazo[5,1-d][1,2,3,5]tetrazin-3(4H)-yl)acetic acid		C₈H₈N₆O₃	详情	详情
(V)	66827	2-thioxopyridin-1(2H)-yl 2-(8-carbamoyl-4-methyleneimidazo[5,1-d][1,2,3,5]tetrazin-3(4H)-yl)acetate		C₁₃H₁₁N₇O₃S	详情	详情

Extended Information