(R)-methyl 2-amino-3-(1H-indol-3-yl)propanoate hydrochloride -Drug Synthesis Database

【结构式】

【分子编号】66757

【品名】(R)-methyl 2-amino-3-(1H-indol-3-yl)propanoate hydrochloride

【CA登记号】　

【分子式】C₁₂H₁₄N₂O₂.HCl

【分子量】254.71608

【元素组成】C 56.59% H 5.94% Cl 13.92% N 11% O 12.56%

与该中间体有关的原料药合成路线共 2 条

该中间体在本合成路线中的序号：(II)

【1】 Jiang WQ, Alford VC, Qiu YH. 2004. Synthesis and SAR of tetracyclic pyrroloquinolones as phosphodies-terase 5 inhibitors. Bioorg Med Chem, 12(6):1505～1515
【2】 Orme MW, Maninelli MJ, Doecke CW, et aL. 2004. Preparation of tetrahydro-β-carboline diastereomers by modified Pictet-Spengler reaction. W0 2004011463

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(III)	10127	1,3-Benzodioxole-5-carbaldehyde; Heliotropine	120-57-0	C₈H₆O₃	详情	详情
(I)	66756	(R)-2-amino-3-(1H-indol-3-yl)propanoic acid		C₁₁H₁₂N₂O₂	详情	详情
(II)	66757	(R)-methyl 2-amino-3-(1H-indol-3-yl)propanoate hydrochloride		C₁₂H₁₄N₂O₂.HCl	详情	详情
(IV)	66758	methyl (1R,3R)-1-(1,3-benzodioxol-5-yl)-2,3,4,9-tetrahydro-1H-beta-carboline-3-carboxylate hydrochloride		C₂₀H₁₈N₂O₄.HCl	详情	详情
(V)	43791	methyl (1R,3R)-1-(1,3-benzodioxol-5-yl)-2-(2-chloroacetyl)-2,3,4,9-tetrahydro-1H-beta-carboline-3-carboxylate		C₂₂H₁₉ClN₂O₅	详情	详情

该中间体在本合成路线中的序号： (I)

【1】 Revell JD, Srinivasan N, Ganesan A. 2004. Two concise syntheses of Cialis via the N-acyliminium Pictet-Spengler reaction. Synlett, (8):1428～1430

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	66757	(R)-methyl 2-amino-3-(1H-indol-3-yl)propanoate hydrochloride		C₁₂H₁₄N₂O₂.HCl	详情	详情
(V)	66761	(1R,3R)-methyl 2-(2-((((9H-fluoren-9-yl)methoxy)carbonyl)(methyl)amino)acetyl)-1-(benzo[d][1,3]dioxol-5-yl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylate		C₃₈H₃₃N₃O₇	详情	详情
(II)	10127	1,3-Benzodioxole-5-carbaldehyde; Heliotropine	120-57-0	C₈H₆O₃	详情	详情
(III)	66759	(R,E)-methyl 2-((benzo[d][1,3]dioxol-5-ylmethylene)amino)-3-(1H-indol-3-yl)propanoate		C₂₀H₁₈N₂O₄	详情	详情
(IV)	66760	(9H-fluoren-9-yl)methyl (2-chloro-2-oxoethyl)(methyl)carbamate		C₁₈H₁₆ClNO₃	详情	详情

Extended Information