11-(4-(dimethylamino)phenyl)-13-methyl-17-(3-((tetrahydro-2H-pyran-2-yl)oxy)prop-1-yn-1-yl)-1,2,4,5,6,7,8,11,12,13,14,15,16,17-tetradecahydrospiro[cyclopenta[a]phenanthrene-3,2'-[1,3]dioxolane]-5,17-diol -Drug Synthesis Database

【结构式】

【分子编号】66530

【品名】11-(4-(dimethylamino)phenyl)-13-methyl-17-(3-((tetrahydro-2H-pyran-2-yl)oxy)prop-1-yn-1-yl)-1,2,4,5,6,7,8,11,12,13,14,15,16,17-tetradecahydrospiro[cyclopenta[a]phenanthrene-3,2'-[1,3]dioxolane]-5,17-diol

【CA登记号】　　

【分子式】C₃₆H₄₉NO₆

【分子量】591.788

【元素组成】C 73.07% H 8.35% N 2.37% O 16.22%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(VII)

参考文献中间体

合成目标

【1】 Neef G.Beier S,Elger W, et aL 1984. New steroids with antiprogestational and antiglucocorticoid activities Steroids, 44 (4): 349～372
【2】 Wiechert R.Ned G 1987. Synthesis of antiprogestational steroids. J Steroid Biochem, 27 (4-6): 851～858

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	66526	13-methyl-1,2,4,6,7,8,12,13,14,15,16,17-dodecahydrospiro[5,10-epoxycyclopenta[a]phenanthrene-3,2'-[1,3]dioxolan]-17-ol		C₂₀H₂₈O₄	详情	详情
(II)	10863	Bromo[4-(dimethylamino)phenyl]magnesium	7353-91-5	C₈H₁₀BrMgN	详情	详情
(III)	66527	11-(4-(dimethylamino)phenyl)-13-methyl-1,2,4,5,6,7,8,11,12,13,14,15,16,17-tetradecahydrospiro[cyclopenta[a]phenanthrene-3,2'-[1,3]dioxolane]-5,17-diol		C₂₈H₃₉NO₄	详情	详情
(IV)	66528	11-(4-(dimethylamino)phenyl)-5-hydroxy-13-methyl-1,2,5,6,7,8,11,12,13,14,15,16-dodecahydrospiro[cyclopenta[a]phenanthrene-3,2'-[1,3]dioxolan]-17(4H)-one		C₂₈H₃₇NO₄	详情	详情
(V)	66529			C₂₈H₃₇NO₄	详情	详情
(VI)	43835	2-propynyl tetrahydro-2H-pyran-2-yl ether; 2-(2-propynyloxy)tetrahydro-2H-pyran	6089-04-9	C₈H₁₂O₂	详情	详情
(VII)	66530	11-(4-(dimethylamino)phenyl)-13-methyl-17-(3-((tetrahydro-2H-pyran-2-yl)oxy)prop-1-yn-1-yl)-1,2,4,5,6,7,8,11,12,13,14,15,16,17-tetradecahydrospiro[cyclopenta[a]phenanthrene-3,2'-[1,3]dioxolane]-5,17-diol		C₃₆H₄₉NO₆	详情	详情

Extended Information