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【结 构 式】

【分子编号】66316

【品名】4-amino-1-((2S,5R)-2-(((tert-butyldiphenylsilyl)oxy)methyl)-1,3-oxathiolan-5-yl)-5-fluoropyrimidin-2(1H)-one

【CA登记号】 

【 分 子 式 】C24H28FN3O3SSi

【 分 子 量 】485.655

【元素组成】C 59.36% H 5.81% F 3.91% N 8.65% O 9.88% S 6.60% Si 5.78%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号:(IX)

 

1 Liotta DC, Schinazi RF, et al.1993. The preparation of 2'-deoxy-5-fluoro-3'-thiacytidine and related compounds as anti-HIV nucleosides. US 5210085
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(I) 12234 2-Propen-1-ol; Allyl alcohol 107-18-6 C3H6O 详情 详情
(II) 66313 tert-Butylchlorodiphenylsilane;tert-Butyldiphenylchlorosilane;tert-Butyldiphenylsilyl chloride 58479-61-1 C16H19ClSi 详情 详情
(III) 66314 (allyloxy)(tert-butyl)diphenylsilane   C19H24OSi 详情 详情
(IV) 44475 2-[[tert-butyl(diphenyl)silyl]oxy]acetaldehyde C18H22O2Si 详情 详情
(V) 18524 2-sulfanylacetic acid 68-11-1 C2H4O2S 详情 详情
(VI) 66315 2-(((tert-butyldiphenylsilyl)oxy)methyl)-1,3-oxathiolan-5-one   C20H24O3SSi 详情 详情
(VII) 55072 (2R)-2-({[tert-butyl(diphenyl)silyl]oxy}methyl)-1,3-oxathiolan-4-yl acetate C22H28O4SSi 详情 详情
(VIII) 36959 5-fluoro-N-(trimethylsilyl)-2-[(trimethylsilyl)oxy]-4-pyrimidinamine; N-[5-fluoro-2-[(trimethylsilyl)oxy]-4-pyrimidinyl]-N-(trimethylsilyl)amine C10H20FN3OSi2 详情 详情
(IX) 66316 4-amino-1-((2S,5R)-2-(((tert-butyldiphenylsilyl)oxy)methyl)-1,3-oxathiolan-5-yl)-5-fluoropyrimidin-2(1H)-one   C24H28FN3O3SSi 详情 详情
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