1-(chloromethyl)-2-methylbenzene -Drug Synthesis Database

【结构式】

【分子编号】64834

【品名】1-(chloromethyl)-2-methylbenzene

【CA登记号】

【分子式】C₈H₉Cl

【分子量】140.61216

【元素组成】C 68.34% H 6.45% Cl 25.21%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(V)

2-Hydroxycinnamic acid (I) is converted to its methyl ester (II) by treatment with diazomethane. After reduction of the ester (II) with DIBAL, the resultant cinnamyl alcohol (III) is oxidized to aldehyde (IV) using manganese dioxide. Finally, the phenol (IV) is alkylated with the benzyl halide (V) to yield the corresponding benzyl ether.

参考文献中间体

合成目标

【1】 Jeong, H.-W.; Kim, M.-R.; Son, K.-H.; Han, M.Y.; Ha, J.-H.; Garnier, M.; Meijer, L.; Kwon, B.-M.; Cinnamaldehydes inhibit cyclin dependent kinase 4/cyclin D1. Bioorg Med Chem Lett 2000, 10, 16, 1819.

中间体序号	中间体编号	品名	分子式	供应商	用于合成
(I)	64830	(E)-3-(2-hydroxyphenyl)-2-propenoic acid	C₉H₈O₃	详情	详情
(II)	64931	phenylmethyl 2-{[3-{[(1,1-dimethylethyl)(diphenyl)silyl]oxy}-2-(methyloxy)propanoyl]amino}-4-methylpentanoate	C₃₃H₄₃NO₅Si	详情	详情
(III)	64832	2-[(E)-3-hydroxy-1-propenyl]phenol	C₉H₁₀O₂	详情	详情
(IV)	64833	(E)-3-(2-hydroxyphenyl)-2-propenal	C₉H₈O₂	详情	详情
(V)	64834	1-(chloromethyl)-2-methylbenzene	C₈H₉Cl	详情	详情

Extended Information