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【结 构 式】

【分子编号】64833

【品名】(E)-3-(2-hydroxyphenyl)-2-propenal

【CA登记号】

【 分 子 式 】C9H8O2

【 分 子 量 】148.16132

【元素组成】C 72.96% H 5.44% O 21.6%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号:(IV)

2-Hydroxycinnamic acid (I) is converted to its methyl ester (II) by treatment with diazomethane. After reduction of the ester (II) with DIBAL, the resultant cinnamyl alcohol (III) is oxidized to aldehyde (IV) using manganese dioxide. Finally, the phenol (IV) is alkylated with the benzyl halide (V) to yield the corresponding benzyl ether.

1 Jeong, H.-W.; Kim, M.-R.; Son, K.-H.; Han, M.Y.; Ha, J.-H.; Garnier, M.; Meijer, L.; Kwon, B.-M.; Cinnamaldehydes inhibit cyclin dependent kinase 4/cyclin D1. Bioorg Med Chem Lett 2000, 10, 16, 1819.
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(I) 64830 (E)-3-(2-hydroxyphenyl)-2-propenoic acid C9H8O3 详情 详情
(II) 64931 phenylmethyl 2-{[3-{[(1,1-dimethylethyl)(diphenyl)silyl]oxy}-2-(methyloxy)propanoyl]amino}-4-methylpentanoate C33H43NO5Si 详情 详情
(III) 64832 2-[(E)-3-hydroxy-1-propenyl]phenol C9H10O2 详情 详情
(IV) 64833 (E)-3-(2-hydroxyphenyl)-2-propenal C9H8O2 详情 详情
(V) 64834 1-(chloromethyl)-2-methylbenzene C8H9Cl 详情 详情
Extended Information