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【结 构 式】 
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【药物名称】CB-403 【化学名称】 【CA登记号】302356-18-9 【 分 子 式 】C17H16O2 【 分 子 量 】252.31587 |
【开发单位】Korea Res. Inst. Biosci. Biotechnol. (Originator) 【药理作用】Oncolytic Drugs, CDK4/Cyclin D1 Inhibitors, Inhibitors of Signal Transduction Pathways |
合成路线1
2-Hydroxycinnamic acid (I) is converted to its methyl ester (II) by treatment with diazomethane. After reduction of the ester (II) with DIBAL, the resultant cinnamyl alcohol (III) is oxidized to aldehyde (IV) using manganese dioxide. Finally, the phenol (IV) is alkylated with the benzyl halide (V) to yield the corresponding benzyl ether.
| 【1】 Jeong, H.-W.; Kim, M.-R.; Son, K.-H.; Han, M.Y.; Ha, J.-H.; Garnier, M.; Meijer, L.; Kwon, B.-M.; Cinnamaldehydes inhibit cyclin dependent kinase 4/cyclin D1. Bioorg Med Chem Lett 2000, 10, 16, 1819. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 64830 | (E)-3-(2-hydroxyphenyl)-2-propenoic acid | C9H8O3 | 详情 | 详情 | |
| (II) | 64931 | phenylmethyl 2-{[3-{[(1,1-dimethylethyl)(diphenyl)silyl]oxy}-2-(methyloxy)propanoyl]amino}-4-methylpentanoate | C33H43NO5Si | 详情 | 详情 | |
| (III) | 64832 | 2-[(E)-3-hydroxy-1-propenyl]phenol | C9H10O2 | 详情 | 详情 | |
| (IV) | 64833 | (E)-3-(2-hydroxyphenyl)-2-propenal | C9H8O2 | 详情 | 详情 | |
| (V) | 64834 | 1-(chloromethyl)-2-methylbenzene | C8H9Cl | 详情 | 详情 |
Extended Information