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【结 构 式】

【分子编号】64108

【品名】5-chloro-2-{[(4-chloro-3-nitrophenyl)sulfonyl]amino}benzoyl chloride

【CA登记号】

【 分 子 式 】C13H7Cl3N2O5S

【 分 子 量 】409.63316

【元素组成】C 38.12% H 1.72% Cl 25.96% N 6.84% O 19.53% S 7.83%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号:(V)

Condensation of anthranilic acid (I) with 4-chloro-3-nitrobenzenesulfonyl chloride (II) in the presence of Na2CO3 affords sulfonamide (III). Electrophilic chlorination of (III) employing sulfuryl chloride in hot AcOH leads to (IV). After activation of acid (IV) as the corresponding acid chloride (V), coupling with 4-chloroaniline (VI) furnishes the target anthranilamide.

1 Allanson, N.M.; Thomas, M.G. (PanTherix Ltd.); Bactericidal benzamide derivs.. GB 2365426 .
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(I) 11661 2-Aminobenzoic acid;Anthranilic acid; o-Aminobenzoic acid 118-92-3 C7H7NO2 详情 详情
(II) 42319 tert-butyl (2S)-1-[(4-chloro-3-nitrophenyl)sulfonyl]-2-pyrrolidinecarboxylate C15H19ClN2O6S 详情 详情
(III) 64106 2-{[(4-chloro-3-nitrophenyl)sulfonyl]amino}benzoic acid C13H9ClN2O6S 详情 详情
(IV) 64107 5-chloro-2-{[(4-chloro-3-nitrophenyl)sulfonyl]amino}benzoic acid C13H8Cl2N2O6S 详情 详情
(V) 64108 5-chloro-2-{[(4-chloro-3-nitrophenyl)sulfonyl]amino}benzoyl chloride C13H7Cl3N2O5S 详情 详情
(VI) 12034 4-Chlorophenylamine; 4-Chloroaniline; p-Chloroaniline 106-47-8 C6H6ClN 详情 详情
Extended Information