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【结 构 式】 
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【分子编号】63712 【品名】2-(1-oxo-1,3,4,5-tetrahydro-2H-2-benzazepin-2-yl)acetaldehyde 【CA登记号】 |
【 分 子 式 】C12H13NO2 【 分 子 量 】203.24076 【元素组成】C 70.92% H 6.45% N 6.89% O 15.74% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(IV)Benzazepinone (I) is alkylated by allyl bromide (II) in the presence of NaH to furnish (III). Ozonolysis of the N-allyl group of (III) in cold CH2Cl2 then produces aldehyde (IV). This is then reductively aminated with 5-fluoro-1-(piperidin-4-yl)-2,3-dihydro-1H-benzimidazol-2-one (V) employing NaBH(OAc)3 in 1,2-dichloroethane to yield the title compound.
| 【1】 Forbes, I.T.; Cooper, D.G.; Dodds, E.K.; Douglas, S.E.; Gribble, A.D.; Ife, R.J.; Lightfoot, A.P.; Meeson, M.; Campbell, L.P.; Coleman, T.; Riley, G.J.; Thomas, D.R.; Identification of a novel series of selective 5-HT7 receptor antagonists. Bioorg Med Chem Lett 2003, 13, 6, 1055. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 63710 | 2,3,4,5-tetrahydro-1H-2-benzazepin-1-one | C10H11NO | 详情 | 详情 | |
| (II) | 11463 | 3-Bromo-1-propene; 3-Bromopropene；allyl bromide | 106-95-6 | C3H5Br | 详情 | 详情 |
| (III) | 63711 | 2-(2-propenyl)-2,3,4,5-tetrahydro-1H-2-benzazepin-1-one | C13H15NO | 详情 | 详情 | |
| (IV) | 63712 | 2-(1-oxo-1,3,4,5-tetrahydro-2H-2-benzazepin-2-yl)acetaldehyde | C12H13NO2 | 详情 | 详情 | |
| (V) | 63713 | 5-fluoro-1-(4-piperidinyl)-1,3-dihydro-2H-benzimidazol-2-one | C12H14FN3O | 详情 | 详情 |
Extended Information