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【结 构 式】 
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【药物名称】SB-691673 【化学名称】2-[2-[4-(5-Fluoro-2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)piperidin-1-yl]ethyl]-2,3,4,5-tetrahydro-1H-2-benzazepin-1-one 【CA登记号】 【 分 子 式 】C24H27FN4O2 【 分 子 量 】422.50679 |
【开发单位】GlaxoSmithKline (Originator) 【药理作用】Antidepressants, Mood Disorders, Treatment of, PSYCHOPHARMACOLOGIC DRUGS, Sleep Disorders, Treatment of, 5-HT7 Antagonists |
合成路线1
Benzazepinone (I) is alkylated by allyl bromide (II) in the presence of NaH to furnish (III). Ozonolysis of the N-allyl group of (III) in cold CH2Cl2 then produces aldehyde (IV). This is then reductively aminated with 5-fluoro-1-(piperidin-4-yl)-2,3-dihydro-1H-benzimidazol-2-one (V) employing NaBH(OAc)3 in 1,2-dichloroethane to yield the title compound.
| 【1】 Forbes, I.T.; Cooper, D.G.; Dodds, E.K.; Douglas, S.E.; Gribble, A.D.; Ife, R.J.; Lightfoot, A.P.; Meeson, M.; Campbell, L.P.; Coleman, T.; Riley, G.J.; Thomas, D.R.; Identification of a novel series of selective 5-HT7 receptor antagonists. Bioorg Med Chem Lett 2003, 13, 6, 1055. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 63710 | 2,3,4,5-tetrahydro-1H-2-benzazepin-1-one | C10H11NO | 详情 | 详情 | |
| (II) | 11463 | 3-Bromo-1-propene; 3-Bromopropene；allyl bromide | 106-95-6 | C3H5Br | 详情 | 详情 |
| (III) | 63711 | 2-(2-propenyl)-2,3,4,5-tetrahydro-1H-2-benzazepin-1-one | C13H15NO | 详情 | 详情 | |
| (IV) | 63712 | 2-(1-oxo-1,3,4,5-tetrahydro-2H-2-benzazepin-2-yl)acetaldehyde | C12H13NO2 | 详情 | 详情 | |
| (V) | 63713 | 5-fluoro-1-(4-piperidinyl)-1,3-dihydro-2H-benzimidazol-2-one | C12H14FN3O | 详情 | 详情 |
Extended Information