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【结 构 式】

【分子编号】63711

【品名】2-(2-propenyl)-2,3,4,5-tetrahydro-1H-2-benzazepin-1-one

【CA登记号】

【 分 子 式 】C13H15NO

【 分 子 量 】201.26824

【元素组成】C 77.58% H 7.51% N 6.96% O 7.95%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号:(III)

Benzazepinone (I) is alkylated by allyl bromide (II) in the presence of NaH to furnish (III). Ozonolysis of the N-allyl group of (III) in cold CH2Cl2 then produces aldehyde (IV). This is then reductively aminated with 5-fluoro-1-(piperidin-4-yl)-2,3-dihydro-1H-benzimidazol-2-one (V) employing NaBH(OAc)3 in 1,2-dichloroethane to yield the title compound.

1 Forbes, I.T.; Cooper, D.G.; Dodds, E.K.; Douglas, S.E.; Gribble, A.D.; Ife, R.J.; Lightfoot, A.P.; Meeson, M.; Campbell, L.P.; Coleman, T.; Riley, G.J.; Thomas, D.R.; Identification of a novel series of selective 5-HT7 receptor antagonists. Bioorg Med Chem Lett 2003, 13, 6, 1055.
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(I) 63710 2,3,4,5-tetrahydro-1H-2-benzazepin-1-one C10H11NO 详情 详情
(II) 11463 3-Bromo-1-propene; 3-Bromopropene;allyl bromide 106-95-6 C3H5Br 详情 详情
(III) 63711 2-(2-propenyl)-2,3,4,5-tetrahydro-1H-2-benzazepin-1-one C13H15NO 详情 详情
(IV) 63712 2-(1-oxo-1,3,4,5-tetrahydro-2H-2-benzazepin-2-yl)acetaldehyde C12H13NO2 详情 详情
(V) 63713 5-fluoro-1-(4-piperidinyl)-1,3-dihydro-2H-benzimidazol-2-one C12H14FN3O 详情 详情
Extended Information