1-(2-chloroethyl)-4-(3-chlorophenyl)piperazine -Drug Synthesis Database

【结构式】

【分子编号】63473

【品名】1-(2-chloroethyl)-4-(3-chlorophenyl)piperazine

【CA登记号】

【分子式】C₁₂H₁₆Cl₂N₂

【分子量】259.17792

【元素组成】C 55.61% H 6.22% Cl 27.36% N 10.81%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(II)

N-(3-Chlorophenyl)piperazine (I) is alkylated with 1-bromo-2-chloroethane in the presence of NaOH in DMSO to afford the (2-chloroethyl)piperazine (II). Subsequent condensation of alkyl chloride (II) with 4,5,6,7-tetrahydro-1H-indol-4-one (III) gives rise to the title compound

参考文献中间体

合成目标

【1】 Foreman, M.M.; Helton, D.R.; Glasky, A.J.; Fick, D.B. (Spectrum Pharmaceuticals, Inc.); Tetrahydroindolone and purine derivs. linked to arylpiperazines. WO 0311396 .

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	22114	1-(3-chlorophenyl)piperazine	6640-24-0	C₁₀H₁₃ClN₂	详情	详情
(II)	63473	1-(2-chloroethyl)-4-(3-chlorophenyl)piperazine		C₁₂H₁₆Cl₂N₂	详情	详情
(III)	63474	2-bromo-4-pyridinamine; 2-bromo-4-pyridinylamine		C₅H₅BrN₂	详情	详情

Extended Information