SPI-376, NEO-376, -Drug Synthesis Database

【结构式】

【药物名称】SPI-376, NEO-376

【化学名称】1-[2-[4-(3-Chlorophenyl)piperazin-1-yl]ethyl]-4,5,6,7-tetrahydro-1H-indol-4-one

【CA登记号】496921-73-4, 496921-74-5 (oxalate)

【分子式】C₂₀H₂₄ClN₃O

【分子量】357.88678

【开发单位】Spectrum Pharmaceuticals (Originator)

【药理作用】Antipsychotic Drugs, PSYCHOPHARMACOLOGIC DRUGS, 5-HT1A Receptor Agonists, Dopamine D4 Antagonists

合成路线1

N-(3-Chlorophenyl)piperazine (I) is alkylated with 1-bromo-2-chloroethane in the presence of NaOH in DMSO to afford the (2-chloroethyl)piperazine (II). Subsequent condensation of alkyl chloride (II) with 4,5,6,7-tetrahydro-1H-indol-4-one (III) gives rise to the title compound

参考文献中间体

【1】 Foreman, M.M.; Helton, D.R.; Glasky, A.J.; Fick, D.B. (Spectrum Pharmaceuticals, Inc.); Tetrahydroindolone and purine derivs. linked to arylpiperazines. WO 0311396 .

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	22114	1-(3-chlorophenyl)piperazine	6640-24-0	C₁₀H₁₃ClN₂	详情	详情
(II)	63473	1-(2-chloroethyl)-4-(3-chlorophenyl)piperazine		C₁₂H₁₆Cl₂N₂	详情	详情
(III)	63474	2-bromo-4-pyridinamine; 2-bromo-4-pyridinylamine		C₅H₅BrN₂	详情	详情

Extended Information

Drug NewChemical Entity Original Patent(1)