2-chloro-5-methoxy-6-methyl-1H-indole-3-carbaldehyde -Drug Synthesis Database

【结构式】

【分子编号】63257

【品名】2-chloro-5-methoxy-6-methyl-1H-indole-3-carbaldehyde

【CA登记号】

【分子式】C₁₁H₁₀ClNO₂

【分子量】223.65864

【元素组成】C 59.07% H 4.51% Cl 15.85% N 6.26% O 14.31%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(II)

The Vilsmeier formylation of 5-methoxy-6-methyloxindole (I) with DMF/POCl3 gives rise to the chloro aldehyde (II). This is then condensed with oxindole (III) in methanol in the presence of piperidine to furnish the target bis-indole derivative.

参考文献中间体

合成目标

【1】 Andreani, A.; et al.; Synthesis and antitumor activity of 1,5,6-substituted E-3-(2-chloro-3-indolylmethylene)-1,3-dihydroindol-2-ones. J Med Chem 2002, 45, 12, 2666.

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	63256	5-methoxy-6-methyl-1,3-dihydro-2H-indol-2-one		C₁₀H₁₁NO₂	详情	详情
(II)	63257	2-chloro-5-methoxy-6-methyl-1H-indole-3-carbaldehyde		C₁₁H₁₀ClNO₂	详情	详情
(III)	18699	1,3-dihydro-2H-indol-2-one	59-48-3	C₈H₇NO	详情	详情

Extended Information