NSC-711616, -Drug Synthesis Database

【结构式】

【药物名称】NSC-711616

【化学名称】(E)-3-(2-Chloro-5-methoxy-6-methyl-1H-indol-3-ylmethylidene)-2,3-dihydro-1H-indol-2-one

【CA登记号】

【分子式】C₁₉H₁₅ClN₂O₂

【分子量】338.7966

【开发单位】Lithuanian Institute of Cardiology (Originator), Università degli Studi di Bologna (Originator)

【药理作用】ONCOLYTIC DRUGS

合成路线1

The Vilsmeier formylation of 5-methoxy-6-methyloxindole (I) with DMF/POCl3 gives rise to the chloro aldehyde (II). This is then condensed with oxindole (III) in methanol in the presence of piperidine to furnish the target bis-indole derivative.

参考文献中间体

【1】 Andreani, A.; et al.; Synthesis and antitumor activity of 1,5,6-substituted E-3-(2-chloro-3-indolylmethylene)-1,3-dihydroindol-2-ones. J Med Chem 2002, 45, 12, 2666.

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	63256	5-methoxy-6-methyl-1,3-dihydro-2H-indol-2-one		C₁₀H₁₁NO₂	详情	详情
(II)	63257	2-chloro-5-methoxy-6-methyl-1H-indole-3-carbaldehyde		C₁₁H₁₀ClNO₂	详情	详情
(III)	18699	1,3-dihydro-2H-indol-2-one	59-48-3	C₈H₇NO	详情	详情

Extended Information

Drug NewChemical Entity Original Patent(1)