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【结 构 式】

【分子编号】63256

【品名】5-methoxy-6-methyl-1,3-dihydro-2H-indol-2-one

【CA登记号】

【 分 子 式 】C10H11NO2

【 分 子 量 】177.20288

【元素组成】C 67.78% H 6.26% N 7.9% O 18.06%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号:(I)

The Vilsmeier formylation of 5-methoxy-6-methyloxindole (I) with DMF/POCl3 gives rise to the chloro aldehyde (II). This is then condensed with oxindole (III) in methanol in the presence of piperidine to furnish the target bis-indole derivative.

1 Andreani, A.; et al.; Synthesis and antitumor activity of 1,5,6-substituted E-3-(2-chloro-3-indolylmethylene)-1,3-dihydroindol-2-ones. J Med Chem 2002, 45, 12, 2666.
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(I) 63256 5-methoxy-6-methyl-1,3-dihydro-2H-indol-2-one C10H11NO2 详情 详情
(II) 63257 2-chloro-5-methoxy-6-methyl-1H-indole-3-carbaldehyde C11H10ClNO2 详情 详情
(III) 18699 1,3-dihydro-2H-indol-2-one 59-48-3 C8H7NO 详情 详情
Extended Information