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【结 构 式】 
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【分子编号】63256 【品名】5-methoxy-6-methyl-1,3-dihydro-2H-indol-2-one 【CA登记号】 |
【 分 子 式 】C10H11NO2 【 分 子 量 】177.20288 【元素组成】C 67.78% H 6.26% N 7.9% O 18.06% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(I)The Vilsmeier formylation of 5-methoxy-6-methyloxindole (I) with DMF/POCl3 gives rise to the chloro aldehyde (II). This is then condensed with oxindole (III) in methanol in the presence of piperidine to furnish the target bis-indole derivative.
| 【1】 Andreani, A.; et al.; Synthesis and antitumor activity of 1,5,6-substituted E-3-(2-chloro-3-indolylmethylene)-1,3-dihydroindol-2-ones. J Med Chem 2002, 45, 12, 2666. |
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