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【结 构 式】

【分子编号】61659

【品名】ethyl (2Z,6E)-3-allyl-7,11-dimethyl-2,6,10-dodecatrienoate

【CA登记号】

【 分 子 式 】C19H30O2

【 分 子 量 】290.446

【元素组成】C 78.57% H 10.41% O 11.02%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号:(III)

Palladium-catalyzed coupling between the known vinyl triflate (I) and allyl tributyltin (II) provides adduct (III). Then, reduction of the ester function of (III) by means of DIBAL in cold toluene leads to the target allylic alcohol.

1 Gibbs, B.S.; et al.; Novel farnesol and geranylgeraniol analogues: A potential new class of anticancer agents directed against protein prenylation. J Med Chem 1999, 42, 19, 3800.
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(I) 61658 ethyl (2Z,6E)-7,11-dimethyl-3-{[(trifluoromethyl)sulfonyl]oxy}-2,6,10-dodecatrienoate C17H25F3O5S 详情 详情
(II) 61128   C4H8 详情 详情
(III) 61659 ethyl (2Z,6E)-3-allyl-7,11-dimethyl-2,6,10-dodecatrienoate C19H30O2 详情 详情
Extended Information