3-Allyl farnesol, 3-alFOH, -Drug Synthesis Database

【结构式】

【药物名称】3-Allyl farnesol, 3-alFOH

【化学名称】(2Z,6E)-7,11-Dimethyl-3-(2-propenyl)-2,6,10-dodecatrien-1-ol

【CA登记号】247942-40-1

【分子式】C₁₇H₂₈O

【分子量】248.41211

【开发单位】Karmanos Cancer Institute (Originator), Purdue University (Originator), Wayne State University (Originator)

【药理作用】ONCOLYTIC DRUGS, Farnesyl Transferase Inhibitors

合成路线1

Palladium-catalyzed coupling between the known vinyl triflate (I) and allyl tributyltin (II) provides adduct (III). Then, reduction of the ester function of (III) by means of DIBAL in cold toluene leads to the target allylic alcohol.

参考文献中间体

【1】 Gibbs, B.S.; et al.; Novel farnesol and geranylgeraniol analogues: A potential new class of anticancer agents directed against protein prenylation. J Med Chem 1999, 42, 19, 3800.

中间体序号	中间体编号	品名	分子式	供应商	用于合成
(I)	61658	ethyl (2Z,6E)-7,11-dimethyl-3-{[(trifluoromethyl)sulfonyl]oxy}-2,6,10-dodecatrienoate	C₁₇H₂₅F₃O₅S	详情	详情
(II)	61128		C₄H₈	详情	详情
(III)	61659	ethyl (2Z,6E)-3-allyl-7,11-dimethyl-2,6,10-dodecatrienoate	C₁₉H₃₀O₂	详情	详情

Extended Information

Drug NewChemical Entity Original Patent(1)