ethyl (2Z,6E)-7,11-dimethyl-3-{[(trifluoromethyl)sulfonyl]oxy}-2,6,10-dodecatrienoate -Drug Synthesis Database

【结构式】

【分子编号】61658

【品名】ethyl (2Z,6E)-7,11-dimethyl-3-{[(trifluoromethyl)sulfonyl]oxy}-2,6,10-dodecatrienoate

【CA登记号】

【分子式】C₁₇H₂₅F₃O₅S

【分子量】398.4437096

【元素组成】C 51.25% H 6.32% F 14.3% O 20.08% S 8.05%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(I)

Palladium-catalyzed coupling between the known vinyl triflate (I) and allyl tributyltin (II) provides adduct (III). Then, reduction of the ester function of (III) by means of DIBAL in cold toluene leads to the target allylic alcohol.

参考文献中间体

合成目标

【1】 Gibbs, B.S.; et al.; Novel farnesol and geranylgeraniol analogues: A potential new class of anticancer agents directed against protein prenylation. J Med Chem 1999, 42, 19, 3800.

中间体序号	中间体编号	品名	分子式	供应商	用于合成
(I)	61658	ethyl (2Z,6E)-7,11-dimethyl-3-{[(trifluoromethyl)sulfonyl]oxy}-2,6,10-dodecatrienoate	C₁₇H₂₅F₃O₅S	详情	详情
(II)	61128		C₄H₈	详情	详情
(III)	61659	ethyl (2Z,6E)-3-allyl-7,11-dimethyl-2,6,10-dodecatrienoate	C₁₉H₃₀O₂	详情	详情

Extended Information