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【结 构 式】 
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【分子编号】61431 【品名】4-nitrobenzenediazonium 【CA登记号】 |
【 分 子 式 】C6H4N3O2 【 分 子 量 】150.11678 【元素组成】C 48.01% H 2.69% N 27.99% O 21.32% |
合成路线1
该中间体在本合成路线中的序号：(II)Diazotization of 4-nitroaniline (I), followed by copper-catalyzed coupling of the resultant diazonium salt (II) with 2-furaldehyde (III) leads to 5-(p-nitrophenyl)-2-furancarboxaldehyde (IV) (1). Cyclization of semicarbazideacetic acid (V) by heating in aqueous sulfuric acid leads to 1-aminohydantoin (VI) (2). This is then condensed with aldehyde (IV) to furnish the furfurylidene aminohydantoin (VII) (1, 2). Treatment of (VII) with sodium methoxide gives rise to the corresponding sodium salt (1).
| 【1】 Frimm, R.; Kovac, S.; Giller, S.A.; Furan derivatives. XXIII. Synthesis and absorption spectra of 5-(nitrophenyl)-2-furaldehyde derivatives. Chem Zvesti 1969, 23, 11-12, 916. |
| 【2】 Snyder, H.R. Jr.; Davis, C.S.; Bickerton, R.K.; Halliday, R.P.; 1-[(5-Arylfurfurylidene)amino]hydantoins. A new class of muscle relaxants. J Med Chem 1967, 10, 5, 807. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 15547 | 4-nitrophenylamine; p-Nitroaniline; 4-nitroaniline | 100-01-6 | C6H6N2O2 | 详情 | 详情 |
| (II) | 61431 | 4-nitrobenzenediazonium | C6H4N3O2 | 详情 | 详情 | |
| (III) | 63582 | 2-furaldehyde | C5H4O2 | 详情 | 详情 | |
| (IV) | 63583 | 5-(4-nitrophenyl)-2-furaldehyde | C11H7NO4 | 详情 | 详情 | |
| (V) | 63584 | 2-[1-(aminocarbonyl)hydrazino]acetic acid | C3H7N3O3 | 详情 | 详情 | |
| (VI) | 63585 | 1-amino-2,4-imidazolidinedione | C3H5N3O2 | 详情 | 详情 | |
| (VII) | 63586 | 1-({(E)-[5-(4-nitrophenyl)-2-furyl]methylidene}amino)-2,4-imidazolidinedione | C14H10N4O5 | 详情 | 详情 |
合成路线2
该中间体在本合成路线中的序号：(II)Diazotization of 4-nitroaniline (I) with NaNO2 in cold concentrated HCl produces diazonium salt (II), which is subsequently coupled to 1,4-benzoquinone (III) in the presence of NaHCO3 to furnish the target 2-aryl benzoquinone.
| 【1】 Reynolds, K.; et al.; The identification of nanomolar 1,4-benzoquinone inhibitors of shikimate kinase. 42nd Intersci Conf Antimicrob Agents Chemother (Sept 27 2002, San Diego) 2002, Abst F-745. |