• English
  • 简体中文
Login Register
Current Location: Home > Feedback Help Print

【结 构 式】

【分子编号】63582

【品名】2-furaldehyde

【CA登记号】

【 分 子 式 】C5H4O2

【 分 子 量 】96.08556

【元素组成】C 62.5% H 4.2% O 33.3%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号:(III)

Diazotization of 4-nitroaniline (I), followed by copper-catalyzed coupling of the resultant diazonium salt (II) with 2-furaldehyde (III) leads to 5-(p-nitrophenyl)-2-furancarboxaldehyde (IV) (1). Cyclization of semicarbazideacetic acid (V) by heating in aqueous sulfuric acid leads to 1-aminohydantoin (VI) (2). This is then condensed with aldehyde (IV) to furnish the furfurylidene aminohydantoin (VII) (1, 2). Treatment of (VII) with sodium methoxide gives rise to the corresponding sodium salt (1).

1 Frimm, R.; Kovac, S.; Giller, S.A.; Furan derivatives. XXIII. Synthesis and absorption spectra of 5-(nitrophenyl)-2-furaldehyde derivatives. Chem Zvesti 1969, 23, 11-12, 916.
2 Snyder, H.R. Jr.; Davis, C.S.; Bickerton, R.K.; Halliday, R.P.; 1-[(5-Arylfurfurylidene)amino]hydantoins. A new class of muscle relaxants. J Med Chem 1967, 10, 5, 807.
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(I) 15547 4-nitrophenylamine; p-Nitroaniline; 4-nitroaniline 100-01-6 C6H6N2O2 详情 详情
(II) 61431 4-nitrobenzenediazonium C6H4N3O2 详情 详情
(III) 63582 2-furaldehyde C5H4O2 详情 详情
(IV) 63583 5-(4-nitrophenyl)-2-furaldehyde C11H7NO4 详情 详情
(V) 63584 2-[1-(aminocarbonyl)hydrazino]acetic acid C3H7N3O3 详情 详情
(VI) 63585 1-amino-2,4-imidazolidinedione C3H5N3O2 详情 详情
(VII) 63586 1-({(E)-[5-(4-nitrophenyl)-2-furyl]methylidene}amino)-2,4-imidazolidinedione C14H10N4O5 详情 详情
Extended Information