A-00000762, A-762, -Drug Synthesis Database

【结构式】

【药物名称】A-00000762, A-762

【化学名称】2-(4-Nitrophenyl)benzo-1,4-quinone

【CA登记号】

【分子式】C₁₂H₇NO₄

【分子量】229.19389

【开发单位】Arrow Therapeutics (Originator)

【药理作用】Antibacterial Drugs, ANTIINFECTIVE THERAPY

合成路线1

Diazotization of 4-nitroaniline (I) with NaNO2 in cold concentrated HCl produces diazonium salt (II), which is subsequently coupled to 1,4-benzoquinone (III) in the presence of NaHCO3 to furnish the target 2-aryl benzoquinone.

参考文献中间体

【1】 Reynolds, K.; et al.; The identification of nanomolar 1,4-benzoquinone inhibitors of shikimate kinase. 42nd Intersci Conf Antimicrob Agents Chemother (Sept 27 2002, San Diego) 2002, Abst F-745.

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	15547	4-nitrophenylamine; p-Nitroaniline; 4-nitroaniline	100-01-6	C₆H₆N₂O₂	详情	详情
(II)	61431	4-nitrobenzenediazonium		C₆H₄N₃O₂	详情	详情
(III)	12633	Quinone; Benzo-1,4-quinone; 2,5-Cyclohexadiene-1,4-dione	106-51-4	C₆H₄O₂	详情	详情

Extended Information