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【结 构 式】 
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【分子编号】57817 【品名】4'-(3-chloropropoxy)[1,1'-biphenyl]-4-carbonitrile 【CA登记号】 |
【 分 子 式 】C16H14ClNO 【 分 子 量 】271.746 【元素组成】C 70.72% H 5.19% Cl 13.05% N 5.15% O 5.89% |
合成路线1
该中间体在本合成路线中的序号：(III)Alkylation of 4-cyano-4'-hydroxybiphenyl (I) with 1-bromo-3-chloropropane (II) yields the chloropropyl ether (III). This is then condensed with the mono-protected homopiperazine (IV) to furnish (V). Removal of the N-Boc group of (V) to afford amine (VI) is then accomplished by treatment with trifluoroacetic acid in CH2Cl2. Amine (VI) is subsequently coupled with N-Boc-D-thiazolylalanine (VII) in the presence of EDC/DMAP producing amide (VIII). (1,2)
| 【1】 Curtis, M.P.; Dwight, W.; Fox, G.B.; Esbenshade, T.A.; Pan, J-B.; Bennani, Y.L.; Hancock, A.A.; Faghih, R.; A-320436: Potent human non-imidazole histamine H3 receptor antagonist. 225th ACS Natl Meet (March 23 2003, New Orleans) 2003, Abst MEDI 240. |
| 【2】 Black, L.A.; Faghih, R.; Bennani, Y.L.; Liu, H.; Zhang, H.Q.; Dwight, W.J.; Gentles, R.G.; Phelan, K.M.; Vasudevan, A. (Abbott Laboratories Inc.); Cyclic and bicyclic diamino histamine-3 receptor antagonists. WO 0166534 . |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 48735 | 4-Cyano-4'-hydroxybiphenyl; 4-Hydroxy-4'-cyanodiphenyl; 4'-Cyano-4-biphenylol; 4'-Hydroxy-4-biphenylcarbonitrile | 19812-93-2 | C13H9NO | 详情 | 详情 |
| (II) | 10358 | 1-Bromo-3-chloropropane | 109-70-6 | C3H6BrCl | 详情 | 详情 |
| (III) | 57817 | 4'-(3-chloropropoxy)[1,1'-biphenyl]-4-carbonitrile | C16H14ClNO | 详情 | 详情 | |
| (IV) | 54079 | tert-Butyl 1-homopiperazine carboxylate | n/a | C10H20N2O2 | 详情 | 详情 |
| (V) | 64053 | 1,1-dimethylethyl 4-{3-[(4'-cyano[1,1'-biphenyl]-4-yl)oxy]propyl}-1,4-diazepane-1-carboxylate | C26H33N3O3 | 详情 | 详情 | |
| (VI) | 64054 | 4'-{[3-(1,4-diazepan-1-yl)propyl]oxy}[1,1'-biphenyl]-4-carbonitrile | C21H25N3O | 详情 | 详情 | |
| (VII) | 12882 | (2S)-2-[(tert-Butoxycarbonyl)amino]-3-(1,3-thiazol-4-yl)propionic acid | C11H16N2O4S | 详情 | 详情 | |
| (VIII) | 64055 | 1,1-dimethylethyl 2-(4-{3-[(4'-cyano[1,1'-biphenyl]-4-yl)oxy]propyl}-1,4-diazepan-1-yl)-2-oxo-1-(1,3-thiazol-4-ylmethyl)ethylcarbamate | C32H39N5O4S | 详情 | 详情 |
合成路线2
该中间体在本合成路线中的序号：(I)The title compound is prepared by a displacement reaction between 4'-(3-chloropropoxy)biphenyl-4-carbonitrile (I) and 3(R)-(dimethylamino)pyrrolidine (II) in the presence of K2CO3 and KI in refluxing 2-butanone.
| 【1】 Faghih, R.; Bennani, Y.L.; Dwight, W.J.; Vasudevan, A.; Conner, S.E. (Abbott Laboratories Inc.); 1,3-Disubstd. and 1,3,3-trisubstd. pyrrolidines as histamine-3 receptor ligands and their therapeutic applications. WO 0206223 . |
| 【2】 Faghih, R.; Bennani, Y.L.; Dwight, W.J.; Vasudevan, A.; Conner, S.E. (Abbott Laboratories Inc.); 1,3-Disubstd. and 1,3,3-trisubstd. pyrrolidines as histamine-3 receptor ligands and their therapeutic applications. US 2002035103; US 6515013 . |