A-331440, ABBOTT-331440, -Drug Synthesis Database

【结构式】

【药物名称】A-331440, ABBOTT-331440

【化学名称】4'-[3-[3(R)-(Dimethylamino)pyrrolidin-1-yl]propoxy]biphenyl-4-carbonitrile

【CA登记号】392338-13-5

【分子式】C₂₂H₂₇N₃O

【分子量】349.47999

【开发单位】Abbott (Originator)

【药理作用】Antiobesity Drugs, METABOLIC DRUGS, Treatment of Nutritional Disorders, Histamine H3 Receptor Antagonists

合成路线1

The title compound is prepared by a displacement reaction between 4'-(3-chloropropoxy)biphenyl-4-carbonitrile (I) and 3(R)-(dimethylamino)pyrrolidine (II) in the presence of K2CO3 and KI in refluxing 2-butanone.

参考文献中间体

【1】 Faghih, R.; Bennani, Y.L.; Dwight, W.J.; Vasudevan, A.; Conner, S.E. (Abbott Laboratories Inc.); 1,3-Disubstd. and 1,3,3-trisubstd. pyrrolidines as histamine-3 receptor ligands and their therapeutic applications. WO 0206223 .
【2】 Faghih, R.; Bennani, Y.L.; Dwight, W.J.; Vasudevan, A.; Conner, S.E. (Abbott Laboratories Inc.); 1,3-Disubstd. and 1,3,3-trisubstd. pyrrolidines as histamine-3 receptor ligands and their therapeutic applications. US 2002035103; US 6515013 .

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	57817	4'-(3-chloropropoxy)[1,1'-biphenyl]-4-carbonitrile		C₁₆H₁₄ClNO	详情	详情
(II)	57818	(3R)-N,N-dimethyl-3-pyrrolidinamine; N,N-dimethyl-N-[(3R)pyrrolidinyl]amine	132958-72-6	C₆H₁₄N₂	详情	详情

Extended Information

Drug NewChemical Entity Original Patent(1)