(3R)-N,N-dimethyl-3-pyrrolidinamine; N,N-dimethyl-N-[(3R)pyrrolidinyl]amine -Drug Synthesis Database

【结构式】

【分子编号】57818

【品名】(3R)-N,N-dimethyl-3-pyrrolidinamine; N,N-dimethyl-N-[(3R)pyrrolidinyl]amine

【CA登记号】132958-72-6

【分子式】C₆H₁₄N₂

【分子量】114.19064

【元素组成】C 63.11% H 12.36% N 24.53%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(II)

The title compound is prepared by a displacement reaction between 4'-(3-chloropropoxy)biphenyl-4-carbonitrile (I) and 3(R)-(dimethylamino)pyrrolidine (II) in the presence of K2CO3 and KI in refluxing 2-butanone.

参考文献中间体

合成目标

【1】 Faghih, R.; Bennani, Y.L.; Dwight, W.J.; Vasudevan, A.; Conner, S.E. (Abbott Laboratories Inc.); 1,3-Disubstd. and 1,3,3-trisubstd. pyrrolidines as histamine-3 receptor ligands and their therapeutic applications. WO 0206223 .
【2】 Faghih, R.; Bennani, Y.L.; Dwight, W.J.; Vasudevan, A.; Conner, S.E. (Abbott Laboratories Inc.); 1,3-Disubstd. and 1,3,3-trisubstd. pyrrolidines as histamine-3 receptor ligands and their therapeutic applications. US 2002035103; US 6515013 .

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	57817	4'-(3-chloropropoxy)[1,1'-biphenyl]-4-carbonitrile		C₁₆H₁₄ClNO	详情	详情
(II)	57818	(3R)-N,N-dimethyl-3-pyrrolidinamine; N,N-dimethyl-N-[(3R)pyrrolidinyl]amine	132958-72-6	C₆H₁₄N₂	详情	详情

Extended Information